Background Genome-wide measures of gene expression can identify patterns of gene activity
that subclassify tumours and might provide a better means than is currently available for …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

Cancer evolves dynamically as clonal expansions supersede one another driven by shifting
selective pressures, mutational processes, and disrupted cancer genes. These processes …

Multiple somatic rearrangements are often found in cancer genomes; however, the underlying
processes of rearrangement and their contribution to cancer development are poorly …

We explored whether the five previously reported molecular subtypes in breast cancer show
a preference for organ-specific relapse and searched for molecular pathways involved. The “…

Approximately 1–5% of breast cancers are attributed to inherited mutations in BRCA1 or
BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other …

The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not
yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (…

Patterns of genomic evolution between primary and metastatic breast cancer have not been
studied in large numbers, despite patients with metastatic breast cancer having dismal …

Identification of specific subtypes of circulating tumor cells in peripheral blood of cancer
patients can provide information about the biology of metastasis and improve patient …

In this study, we quantified 249 mature micro-RNA (miRNA) transcripts in estrogen receptor-positive
(ER + ) primary breast tumors of patients with lymph node-negative (LNN) disease to …