The localization of substance P in brain regions that coordinate stress responses and receive
convergent monoaminergic innervation suggested that substance P antagonists might …

Over residues 15–36, which comprise the H-bonded core of the amyloid fibrils it forms, the
Alzheimer's disease plaque peptide amyloid β (Aβ) possesses a very similar sequence to that …

Although the amyloid fibrils formed from the Alzheimer's disease amyloid peptide Aβ are
rich in cross-β sheet, the peptide likely also exhibits turn and unstructured regions when it …

Aims: To evaluate whether the Asthma Control Test™(ACT) score is predictive of Global
Initiative for Asthma (GINA) guideline-defined classification levels of asthma control. The ACT is …

Many of the debates surrounding the environmental, social, and economic implications of
climate change are now well known. However, there is increasing concern over the extent to …

There are nine known expanded CAG repeat neurological diseases, including Huntington's
disease (HD), each involving the repeat expansion of polyglutamine (polyGln) in a different …

The ability of a single polypeptide sequence to grow into multiple stable amyloid fibrils sets
these aggregates apart from most native globular proteins. The existence of multiple amyloid …

Structural modifications requiring novel synthetic chemistry were made to the morpholine
acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2…

We used surface plasmon resonance biosensors to evaluate the kinetics associated with the
initial events of beta-amyloid (Aβ) fibril elongation. Fibrils were immobilized on the sensor …

Although the gross morphology of amyloid fibrils is fairly well understood, very little is known
about how the constituent polypeptides fold within the amyloid folding motif. In the …