Long-duration γ-ray bursts (GRBs) are thought to result from the explosions of certain massive
stars 1 , and some are bright enough that they should be observable out to redshifts of z > …

Background Evaluation of brain β‐amyloid by positron emission tomography (PET) imaging
can assist in the diagnosis of Alzheimer disease (AD) and other dementias. Methods Open‐…

Aptamers are small oligonucleotides that are selected to bind tightly and specifically to a target
molecule. We sought to determine whether aptamers have potential for in vivo delivery of …

Context. The ESO public survey VISTA variables in the Vía Láctea (VVV) started in 2010. VVV
targets 562 sq. deg in the Galactic bulge and an adjacent plane region and is expected to …

Aptamers are powerful candidates for molecular imaging applications due to a number of
attractive features, including rapid blood clearance and tumor penetration. We carried out …

Background Adrenocortical carcinoma is a rare, aggressive cancer for which few treatment
options are available. Linsitinib (OSI-906) is a potent, oral small molecule inhibitor of both IGF…

A notable example of aptamer plasticity was reported by Smith and colleagues (17), who
used a modified SELEX process to blend high-affinity binding with covalent inhibition of an …

Two new imaging instruments, ‘Alopeke and Zorro, were designed, built, and commissioned
at the Gemini-North and Gemini-South telescopes in 2018 and 2019, respectively. Here we …

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …

18 F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic
feature of Alzheimer disease (AD) and other neurodegenerative disorders. Preclinically, 18 F-…