The MPI Bioinformatics Toolkit (https://toolkit.tuebingen.mpg.de ) is a free, one-stop web
service for protein bioinformatic analysis. It currently offers 34 interconnected external and in-…

The cell nucleus must continually resist and respond to intercellular and intracellular mechanical
forces to transduce mechanical signals and maintain proper genome organization and …

Long-duration γ-ray bursts (GRBs) are thought to result from the explosions of certain massive
stars 1 , and some are bright enough that they should be observable out to redshifts of z > …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 (…

As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical inputs…

Aptamers are small oligonucleotides that are selected to bind tightly and specifically to a target
molecule. We sought to determine whether aptamers have potential for in vivo delivery of …

Background Evaluation of brain β‐amyloid by positron emission tomography (PET) imaging
can assist in the diagnosis of Alzheimer disease (AD) and other dementias. Methods Open‐…

Context. The ESO public survey VISTA variables in the Vía Láctea (VVV) started in 2010. VVV
targets 562 sq. deg in the Galactic bulge and an adjacent plane region and is expected to …

Aptamers are powerful candidates for molecular imaging applications due to a number of
attractive features, including rapid blood clearance and tumor penetration. We carried out …

Background Adrenocortical carcinoma is a rare, aggressive cancer for which few treatment
options are available. Linsitinib (OSI-906) is a potent, oral small molecule inhibitor of both IGF…