User profiles for Andrew M. Rauth
Andrew RauthProfessor Emeritus Medical Biophysics, University of Toronto Verified email at uhnres.utoronto.ca Cited by 11850 |
Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles
The prospect of improved cancer chemotherapy using solid lipid nanoparticles (SLN) as a
drug delivery system is promising. Several obstacles frequently encountered with anticancer …
drug delivery system is promising. Several obstacles frequently encountered with anticancer …
A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system
The objectives of this study were to evaluate the potential of a polymer-lipid hybrid nanoparticle
(PLN) system to enhance cellular accumulation and retention of doxorubicin (Dox), a …
(PLN) system to enhance cellular accumulation and retention of doxorubicin (Dox), a …
A new polymer–lipid hybrid nanoparticle system increases cytotoxicity of doxorubicin against multidrug-resistant human breast cancer cells
Purpose This work is intended to develop and evaluate a new polymer–lipid hybrid nanoparticle
system that can efficiently load and release water-soluble anticancer drug doxorubicin …
system that can efficiently load and release water-soluble anticancer drug doxorubicin …
[PDF][PDF] The physical state of viral nucleic acid and the sensitivity of viruses to ultraviolet light
AM Rauth - Biophysical Journal, 1965 - cell.com
Ultraviolet light action spectra in the range 2250 to 3020 A have been determined for the
plaque-forming ability of the following bacteriophage and animal viruses: T-2, ϕx-174, R-17, fr, …
plaque-forming ability of the following bacteriophage and animal viruses: T-2, ϕx-174, R-17, fr, …
Design of Hybrid MnO2‐Polymer‐Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment
…, PJ O'Brien, RS DaCosta, AM Rauth… - Advanced Functional …, 2015 - Wiley Online Library
Manganese dioxide (MnO 2 ) nanoparticles (NPs) were discovered in previous work to be
effective in improving tumor oxygenation (hypoxia) and reducing H 2 O 2 and acidity in the …
effective in improving tumor oxygenation (hypoxia) and reducing H 2 O 2 and acidity in the …
A novel doxorubicin-mitomycin C co-encapsulated nanoparticle formulation exhibits anti-cancer synergy in multidrug resistant human breast cancer cells
…, RY Cheung, J Manias, A Connor, AM Rauth… - Breast cancer research …, 2010 - Springer
Anthracycline-containing treatment regimens are currently the most widely employed
regimens for the management of breast cancer. These drug combinations are often designed …
regimens for the management of breast cancer. These drug combinations are often designed …
A Novel Solid Lipid Nanoparticle Formulation for Active Targeting to Tumor αvβ3 Integrin Receptors Reveals Cyclic RGD as A Double‐Edged Sword
The overexpression of α v β 3 integrin receptors on tumor cells and tumor vascular
endothelium makes it a useful target for imaging, chemotherapy and anti‐angiogenic therapy. …
endothelium makes it a useful target for imaging, chemotherapy and anti‐angiogenic therapy. …
Hybrid manganese dioxide nanoparticles potentiate radiation therapy by modulating tumor hypoxia
Hypoxia in the tumor microenvironment (TME) mediates resistance to radiotherapy and
contributes to poor prognosis in patients receiving radiotherapy. Here we report the design of …
contributes to poor prognosis in patients receiving radiotherapy. Here we report the design of …
Polymer–lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin–mitomycin C and enable their spatiotemporal co-delivery and local …
Effective combination chemotherapy requires the delivery of drugs of synergism to tumor
sites while sparing normal tissues. Herein we investigated whether coencapsulation of …
sites while sparing normal tissues. Herein we investigated whether coencapsulation of …
[HTML][HTML] Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy–an illustration with firsthand examples
Nanotechnology has been applied extensively in drug delivery to improve the therapeutic
outcomes of various diseases. Tremendous efforts have been focused on the development of …
outcomes of various diseases. Tremendous efforts have been focused on the development of …