Background Chronic psychological stress is associated with accelerated aging and increased
risk for aging-related diseases, but the underlying molecular mechanisms are unclear. …

The link between dysregulated serotonergic activity and depression and anxiety disorders
is well established, yet the molecular mechanisms underlying these psychopathologies are …

Context The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3
patients does not fully recover even after several treatment trials. Genetic factors and clinical …

Major depression (MD) is one of the most prevalent psychiatric disorders and a leading
cause of loss in work productivity. A combination of genetic and environmental risk factors …

Major depressive disorder (MDD) is a very common stress-related mental disorder that carries
a huge burden for affected patients and the society. It is associated with a high mortality …

Depression is a common and often difficult-to-treat clinical condition with a high rate of
patients showing insufficient treatment response and persistence of symptoms. We report the …

Context Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co-chaperone
FKBP5 have been shown to alter GR sensitivity and are associated with an …

Although gene expression profiles in peripheral blood in major depression are not likely to
identify genes directly involved in the pathomechanism of affective disorders, they may serve …

Epigenetic modifications control chromatin structure and function, and thus mediate changes
in gene expression, ultimately influencing protein levels. Recent research indicates that …

The FK 506 binding protein 51 or FKBP5 has been implicated in the regulation of glucocorticoid
receptor ( GR ) sensitivity, and genetic variants in this gene have been associated with …