Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

Various inflammatory diseases are characterized by tissue infiltration of neutrophils. Chemokines
recruit and activate leukocytes, but neutrophils are traditionally known to be restricted …

Upon activation, neutrophils release DNA fibers decorated with antimicrobial proteins,
forming neutrophil extracellular traps (NETs) 1 , 2 , 3 . Although NETs are bactericidal and …

BACKGROUND: Cystic fibrosis (CF) lung disease is characterized by perpetuated neutrophilic
inflammation with progressive tissue destruction. Neutrophils represent the major cellular …

Neutrophils represent the major fraction of circulating immune cells and are rapidly recruited
to sites of infection and inflammation. The inflammasome is a multiprotein complex that …

Pseudomonas aeruginosa persists in patients with cystic fibrosis (CF) and drives CF lung
disease progression. P. aeruginosa potently activates the innate immune system, mainly …

Chronic granulomatous disease (CGD) is the most common inherited disorder of phagocytic
functions, caused by genetic defects in the leukocyte nicotinamide dinucleotide phosphate (…

Significant airway remodelling is a major component of the increased morbidity and
mortality observed in cystic fibrosis (CF) patients. These airways feature ongoing leukocytic …

Chronic obstructive lung disease determines morbidity and mortality of patients with cystic
fibrosis (CF). CF airways are characterized by a nonresolving neutrophilic inflammation. After …

Background ABCA3 transporter (ATP-binding cassette transporter of the A subfamily) is
localized to the limiting membrane of lamellar bodies, organelles for assembly and storage of …