Background Neoadjuvant chemotherapy for unresectable colorectal liver metastases can
downsize tumours for curative resection. We assessed the effectiveness of cetuximab …

Many management strategies exist for neuroendocrine liver metastases. These strategies
range from surgery to ablation with various interventional radiology procedures, and include …

Objective. —Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant
disorder. The 3 recognized subtypes include MEN 2A, characterized by medullary thyroid …

Context: Although the pathogenesis of follicular thyroid carcinoma (FTC) and its relation to
follicular adenoma (FA) remains unclear, detailed understanding of FTC carcinogenesis …

Management of neuroendocrine neoplasia represents a clinical challenge because of its
late presentation, lack of treatment options, and limitations in present imaging modalities and …

The autosomal dominant multiple endocrine neoplasia type 2 syndromes (MEN 2) comprise
three clinically distinct entities, MEN 2A, familial medullary thyroid carcinoma and MEN 2B, …

Increased levels of interleukin (IL)-10 have been described as a negative prognostic
indicator for survival in patients with various types of cancer. IL-10 exerts tolerogenic and …

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) represent a heterogenous
group of tumors arising from a variety of neuroendocrine cell types. The incidence and …

We introduce and validate a new precision oncology framework for the systematic prioritization
of drugs targeting mechanistic tumor dependencies in individual patients. Compounds …

Mutations of the RET proto-oncogene are the underlying cause of some cases of Hlrschsprung
disease (HSCR) and the Inherited cancer syndromes multiple endocrine neoplasia types …