[HTML][HTML] The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival
D Delitto, BS Black, HL Sorenson, AE Knowlton… - BMC cancer, 2015 - Springer
Background The tumor microenvironment impacts pancreatic cancer (PC) development,
progression and metastasis. How intratumoral inflammatory mediators modulate this biology …
progression and metastasis. How intratumoral inflammatory mediators modulate this biology …
[HTML][HTML] Isolation of pancreatic cancer cells from a patient-derived xenograft model allows for practical expansion and preserved heterogeneity in culture
K Pham, D Delitto, AE Knowlton, ER Hartlage… - The American journal of …, 2016 - Elsevier
Commercially available, highly passaged pancreatic cancer (PC) cell lines are of limited
translational value. Attempts to overcome this limitation have primarily consisted of cancer cell …
translational value. Attempts to overcome this limitation have primarily consisted of cancer cell …
Nicotine reduces survival via augmentation of paracrine HGF–MET signaling in the pancreatic cancer microenvironment
D Delitto, D Zhang, S Han, BS Black, AE Knowlton… - Clinical Cancer …, 2016 - AACR
Purpose: The relationship between smoking and pancreatic cancer biology, particularly in
the context of the heterogeneous microenvironment, remains incompletely defined. We …
the context of the heterogeneous microenvironment, remains incompletely defined. We …
Spatial distribution of blood vessels and CD34+ hematopoietic stem and progenitor cells within the marrow cavities of human cancellous bone
…, VA Bourke, JR Lyon, AE Knowlton… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Current bone marrow dosimetry methods inherently assume that the target cells of interest
for the assessment of leukemia risk (stochastic effects) or marrow toxicity (deterministic effects…
for the assessment of leukemia risk (stochastic effects) or marrow toxicity (deterministic effects…
Chlamydial infection induces host cytokinesis failure at abscission
HM Brown, AE Knowlton… - Cellular …, 2012 - Wiley Online Library
C hlamydia trachomatis is an obligate intracellular bacteria and the infectious agent responsible
for the sexually transmitted disease C hlamydia. Infection with C hlamydia can lead to …
for the sexually transmitted disease C hlamydia. Infection with C hlamydia can lead to …
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human …
The cancer microenvironment allows tumor cells to evade immune surveillance through a
variety of mechanisms. While interferon-γ (IFNγ) is central to effective antitumor immunity, its …
variety of mechanisms. While interferon-γ (IFNγ) is central to effective antitumor immunity, its …
Chlamydia trachomatis Infection Causes Mitotic Spindle Pole Defects Independently from its Effects on Centrosome Amplification
AE Knowlton, HM Brown, TS Richards, LA Andreolas… - Traffic, 2011 - Wiley Online Library
Chlamydiae are Gram negative, obligate intracellular bacteria, and Chlamydia trachomatis
is the etiologic agent of the most commonly reported sexually transmitted disease in the …
is the etiologic agent of the most commonly reported sexually transmitted disease in the …
[HTML][HTML] Chlamydia trachomatis homotypic inclusion fusion is promoted by host microtubule trafficking
TS Richards, AE Knowlton, SS Grieshaber - BMC microbiology, 2013 - Springer
Background The developmental cycle of the obligate intracellular pathogen Chlamydia is
dependant on the formation of a unique intracellular niche termed the chlamydial inclusion. …
dependant on the formation of a unique intracellular niche termed the chlamydial inclusion. …
[HTML][HTML] Chlamydia induces anchorage independence in 3T3 cells and detrimental cytological defects in an infection model
AE Knowlton, LJ Fowler, RK Patel, SM Wallet… - PLOS …, 2013 - journals.plos.org
Chlamydia are Gram negative, obligate intracellular bacterial organisms with different species
causing a multitude of infections in both humans and animals. Chlamydia trachomatis is …
causing a multitude of infections in both humans and animals. Chlamydia trachomatis is …
[HTML][HTML] Multinucleation during C. trachomatis Infections Is Caused by the Contribution of Two Effector Pathways
HM Brown, AE Knowlton, E Snavely, BD Nguyen… - PLoS …, 2014 - journals.plos.org
Chlamydia trachomatis is an obligate intracellular bacterial pathogen and the second leading
cause of sexually transmitted infections in the US. Infections cause significant morbidity …
cause of sexually transmitted infections in the US. Infections cause significant morbidity …