The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

Many developments have occurred since the publication of the widely-used 2009 Canadian
Cardiovascular Society (CCS) Dyslipidemia guidelines. Here, we present an updated …

That adult humans possess brown fat is now accepted—but is the brown fat metabolically
active? Does human brown fat actually combust fat to release heat? In this issue of the JCI, …

… Jacques Genest MD1, Ruth McPherson MD PhD2, Jiri Frohlich MD3, Todd Anderson
MD4, Norm Campbell MD4, André Carpentier MD5, Patrick Couture MD6, Robert Dufour …

Context: In humans, the prevalence, mass, and glucose-uptake activity of 18 F-fluorodeoxyglucose
( 18 F-FDG)-detected brown adipose tissue (BAT), which are expectedly enhanced …

A novel animal model of insulin resistance, the fructose-fed Syrian golden hamster, was
employed to investigate the mechanisms mediating the overproduction of very low density …

Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an
attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3 -…

The associations between obesity, insulin resistance, and type 2 diabetes mellitus are well
documented. Free fatty acids (FFA), which are often elevated in obesity, have been …

Context: Recent studies examining brown adipose tissue (BAT) metabolism in adult
humans have provided convincing evidence of its thermogenic potential and role in clearing …

The in vivo effect of elevated free fatty acids (FFA) on β-cell function in humans remains
extremely controversial. We examined, in healthy young men, the acute (90 min) and chronic (48 …