Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term
management to optimise patient outcomes. The Pituitary Society convened a consensus …

The 13th Acromegaly Consensus Conference was held in November 2019 in Fort
Lauderdale, Florida, and comprised acromegaly experts including endocrinologists and …

Cushing disease is a condition in which the pituitary gland releases excessive adrenocorticotropic
hormone (ACTH) as a result of an adenoma arising from the ACTH-secreting cells in …

Acromegaly is a rare disease caused by growth hormone hypersecretion, mostly from a
pituitary adenoma, driving insulin-like growth factor 1 overproduction. Manifestations include …

Somatotropin-release inhibitory factor (SRIF) is a major regulator of pituitary function, mostly
inhibiting hormone secretion and to a lesser extent pituitary cell growth. Five SRIF receptor …

Cushing disease caused by adrenocorticotropin (ACTH)-secreting pituitary adenomas leads
to hypercortisolemia predisposing to diabetes, hypertension, osteoporosis, central obesity, …

As commonly encountered, pituitary adenomas are invariably benign. We therefore studied
protective pituitary proliferative mechanisms. Pituitary tumor transforming gene (Pttg) …

Cutaneous changes in acromegaly result from excess GH and IGF-1 action on skin cells and
adnexae. Skin puffiness due to dermal glycosaminoglycan accumulation and edema are …

Growth hormone (GH) excess in acromegaly is associated with increased precancerous
colon polyps and soft tissue adenomas, whereas short-stature humans harboring an …

Silent corticotrophins adenomas (SCAs) are clinically silent and non-secreting but
immunostain positively for ACTH. We hypothesize that SCAs comprise both corticotroph and …