Synthesis and preclinical evaluation of 11C-UCB-J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain
The synaptic vesicle glycoprotein 2A (SV2A) is found in secretory vesicles in neurons and
endocrine cells. PET with a selective SV2A radiotracer will allow characterization of drugs that …
endocrine cells. PET with a selective SV2A radiotracer will allow characterization of drugs that …
[HTML][HTML] City-scale agent-based simulators for the study of non-pharmaceutical interventions in the context of the COVID-19 epidemic: IISc-TIFR COVID-19 city-scale …
We highlight the usefulness of city-scale agent-based simulators in studying various non-pharmaceutical
interventions to manage an evolving pandemic. We ground our studies in the …
interventions to manage an evolving pandemic. We ground our studies in the …
Activity of P-glycoprotein, a β-amyloid transporter at the blood–brain barrier, is compromised in patients with mild Alzheimer disease
Studies in animals and postmortem human brain tissue support a role for P-glycoprotein in
clearance of cerebral β-amyloid across the blood–brain barrier (BBB). We tested the …
clearance of cerebral β-amyloid across the blood–brain barrier (BBB). We tested the …
Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid
AK Deo, SM Bandiera - Drug metabolism and disposition, 2008 - ASPET
3α,7α,12α-Trihydroxy-5β-cholan-24-oic (cholic) and 3α,7α-dihydroxy-5β-cholan-24-oic (chenodeoxycholic)
acids are the predominant hepatic and biliary bile acids of most mammalian …
acids are the predominant hepatic and biliary bile acids of most mammalian …
Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep −/− mice
E Hrycay, D Forrest, L Liu, R Wang, J Tai, A Deo… - Molecular and cellular …, 2014 - Springer
The bile salt export pump (BSEP/Bsep; gene symbol ABCB11/Abcb11) translocates bile
salts across the hepatocyte canalicular membrane into bile in humans and mice. In humans, …
salts across the hepatocyte canalicular membrane into bile in humans and mice. In humans, …
Biotransformation of lithocholic acid by rat hepatic microsomes: metabolite analysis by liquid chromatography/mass spectrometry
AK Deo, SM Bandiera - Drug metabolism and disposition, 2008 - ASPET
Lithocholic acid is a lipid-soluble hepatotoxic bile acid that accumulates in the liver during
cholestasis. A potential detoxification pathway for lithocholic acid involves hydroxylation by …
cholestasis. A potential detoxification pathway for lithocholic acid involves hydroxylation by …
Confounding parameters in preclinical assessment of blood–brain barrier permeation: an overview with emphasis on species differences and effect of disease states
AK Deo, FP Theil, JM Nicolas - Molecular pharmaceutics, 2013 - ACS Publications
Drug delivery across the brain–blood interfaces is a complex process involving physicochemical
drug properties, transporters, enzymes, and barrier dysfunction in diseased conditions. …
drug properties, transporters, enzymes, and barrier dysfunction in diseased conditions. …
Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass …
Multidrug-associated protein 2 (MRP2) is an efflux transporter that is expressed at the bile
canalicular membrane. To allow in vitro to in vivo extrapolation of the contribution of MRP2 …
canalicular membrane. To allow in vitro to in vivo extrapolation of the contribution of MRP2 …
Modulation of P-glycoprotein at the human blood-brain barrier by quinidine or rifampin treatment: a positron emission tomography imaging study
…, JF Eary, CF Spiekerman, P Hsiao, AK Deo… - Drug Metabolism and …, 2015 - ASPET
Permeability-glycoprotein (P-glycoprotein, P-gp), an efflux transporter at the human blood-brain
barrier (BBB), is a significant obstacle to central nervous system (CNS) delivery of P-gp …
barrier (BBB), is a significant obstacle to central nervous system (CNS) delivery of P-gp …
3-ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acid
AK Deo, SM Bandiera - Drug metabolism and disposition, 2009 - ASPET
3α-Hydroxy-5β-cholan-24-oic (lithocholic) acid is a relatively minor component of hepatic
bile acids in humans but is highly cytotoxic. Hepatic microsomal oxidation offers a potential …
bile acids in humans but is highly cytotoxic. Hepatic microsomal oxidation offers a potential …