User profiles for Amanda J. Boyle
 | Amanda (Amy) BoyleCentre for Addiction and Mental Health; University of Toronto Verified email at camh.ca Cited by 533 |
Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons
Radioimmunotherapy (RIT) aims to selectively deliver radionuclides emitting α-particles, β-particles
or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …
or Auger electrons to tumors by conjugation to monoclonal antibodies (mAbs) that …
Improving PET imaging acquisition and analysis with machine learning: a narrative review with focus on Alzheimer's disease and oncology
IR Duffy, AJ Boyle, N Vasdev - Molecular imaging, 2019 - journals.sagepub.com
Machine learning (ML) algorithms have found increasing utility in the medical imaging field
and numerous applications in the analysis of digital biomarkers within positron emission …
and numerous applications in the analysis of digital biomarkers within positron emission …
Synthesis of polyglutamide-based metal-chelating polymers and their site-specific conjugation to trastuzumab for auger electron radioimmunotherapy
Three types of metal-chelating polymers (MCPs) with hydrazide end groups were synthesized.
(1) The first set of polymers (the F-series) was synthesized with a furan end group, and all …
(1) The first set of polymers (the F-series) was synthesized with a furan end group, and all …
MicroPET/CT imaging of patient-derived pancreatic cancer xenografts implanted subcutaneously or orthotopically in NOD-scid mice using 64Cu-NOTA-panitumumab …
Introduction Our objective was to study microPET/CT imaging of patient-derived pancreatic
cancer xenografts in NOD-scid mice using F(ab') 2 fragments of the fully-human anti-EGFR …
cancer xenografts in NOD-scid mice using F(ab') 2 fragments of the fully-human anti-EGFR …
Metal-chelating polymers (MCPs) with zwitterionic pendant groups complexed to trastuzumab exhibit decreased liver accumulation compared to polyanionic MCP …
Metal-chelating polymers (MCPs) can amplify the radioactivity delivered to cancer cells by
monoclonal antibodies or their Fab fragments. We focus on trastuzumab (tmAb), which is used …
monoclonal antibodies or their Fab fragments. We focus on trastuzumab (tmAb), which is used …
[HTML][HTML] Artificial intelligence for molecular neuroimaging
In recent years, artificial intelligence (AI) or the study of how computers and machines can
gain intelligence, has been increasingly applied to problems in medical imaging, and in …
gain intelligence, has been increasingly applied to problems in medical imaging, and in …
The Effect of Metal-Chelating Polymers (MCPs) for 111In Complexed via the Streptavidin-Biotin System to Trastuzumab Fab Fragments on Tumor and Normal Tissue …
Purpose To study the effects of backbone composition and charge of biotin-functionalized
metal-chelating polymers (Bi-MCPs) for 111 In complexed to streptavidin (SAv)-trastuzumab …
metal-chelating polymers (Bi-MCPs) for 111 In complexed to streptavidin (SAv)-trastuzumab …
[HTML][HTML] Radiosynthesis of [11C] ibrutinib via Pd-mediated [11C] CO carbonylation: preliminary PET imaging in experimental autoimmune encephalomyelitis mice
A Lindberg, AJ Boyle, J Tong, MB Harkness… - Frontiers in Nuclear …, 2021 - frontiersin.org
Ibrutinib is a first generation Bruton’s tyrosine kinase (BTK) inihibitor that has shown efficacy
in autoimmune diseases and has consequently been developed as a positron emission …
in autoimmune diseases and has consequently been developed as a positron emission …
Trastuzumab Labeled to High Specific Activity with 111In by Site-Specific Conjugation to a Metal-Chelating Polymer Exhibits Amplified Auger Electron-Mediated …
Our objective was to evaluate the cytotoxicity toward HER2-positive human breast cancer (BC)
cells of trastuzumab modified site−specifically with a metal-chelating polymer (MCP) that …
cells of trastuzumab modified site−specifically with a metal-chelating polymer (MCP) that …
Biotinylated polyacrylamide-based metal-chelating polymers and their influence on antigen recognition following conjugation to a trastuzumab Fab fragment
… Yijie Lu, Amanda J. Boyle, Ping-Jiang Cao, David Hedley, Raymond M. Reilly, and Mitchell
… Boyle, Jarret Adams, Yijie Lu, Ghislaine Ngo Ndjock Mbong, Sachdev Sidhu, Raymond M. …
… Boyle, Jarret Adams, Yijie Lu, Ghislaine Ngo Ndjock Mbong, Sachdev Sidhu, Raymond M. …