Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common
solid tumor in children. To determine the genetic basis for neuroblastoma, we performed whole…

T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy.
E3 ligases are involved in maintaining the anergic state. However, the specific molecules …

Nuclear factor erythroid-2–related factor 2 (Nrf2) is a redox-sensitive transcription factor that
regulates the expression of electrophile and xenobiotic detoxification enzymes and efflux …

Purpose: Recently, the majority of protein coding genes were sequenced in a collection of
pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of …

Background & Aims The management of pancreatic cysts poses challenges to both patients
and their physicians. We investigated whether a combination of molecular markers and …

Background & Aims Screening of individuals who have a high risk of pancreatic ductal
adenocarcinoma (PDAC), because of genetic factors, frequently leads to identification of …

Purpose Current standard of care conventional imaging modalities (CIM) such as X-ray
computed tomography (CT) and bone scan can be limited for detection of metastatic prostate …

Pancreatic cancer is the fourth leading cause of cancer death in the developed world 1 . Both
inherited high-penetrance mutations in BRCA2 (ref. 2 ), ATM 3 , PALB2 (ref. 4 ), BRCA1 (ref…

The purpose of this study was to evaluate 18 F-FDG PET/CT scanning as an early predictor
of response to immune checkpoint inhibitors (ICIs) in patients with advanced melanoma. …

Objective Although pancreatic ductal adenocarcinoma is considered a rapidly progressive
disease, mathematical models estimate that it takes many years for an initiating pancreatic …