A systematic approach for developing bacteria-specific imaging tracers

…, AM Murawski, S Pokkali, AS Kalinda… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The modern patient is increasingly susceptible to bacterial infections including those due to
multidrug-resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen-…

Positron Emission Tomography Imaging with 2-[18F]F-p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response

…, F Daryaee, J Merino, GE Yoon, AS Kalinda… - ACS infectious …, 2018 - ACS Publications
Staphylococcus aureus is the leading cause of life-threatening infections, frequently
originating from unknown or deep-seated foci. Source control and institution of appropriate …

Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors

MR Bockman, AS Kalinda, R Petrelli… - Journal of medicinal …, 2015 - ACS Publications
Mycobacterium tuberculosis (Mtb), responsible for both latent and symptomatic tuberculosis
(TB), remains the second leading cause of mortality among infectious diseases worldwide. …

Malaria-infected mice are cured by oral administration of new artemisinin derivatives

…, W Maio, AS Rosenthal, AS Kalinda… - Journal of medicinal …, 2008 - ACS Publications
In four or five chemical steps from the 1,2,4-trioxane artemisinin, a new series of 23 trioxane
dimers has been prepared. Eleven of these new trioxane dimers cure malaria-infected mice …

Radiosynthesis and validation of [Carboxy11C]4‐Aminobenzoic acid ([11C]PABA), a PET radiotracer for imaging bacterial infections

DP Holt, AS Kalinda, LE Bambarger… - Journal of Labelled …, 2019 - Wiley Online Library
In this practitioner protocol, the radiochemical synthesis of [ 11 C] PABA is described in
detail, and a quality control summary of three validation productions is presented. The results …

Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate

GH Posner, WA Maio, AS Kalinda - Bioorganic & medicinal chemistry, 2008 - Elsevier
From 9-substituted DHA, several new artemisinin-derived C-10 acetal ethers and esters
were prepared with either a 9-fluoro or a 9-sulfonyl substituent. The very strong inductive …

Radiochemistry

…, C Wagener, LE Bambarger, AS Kalinda… - Imaging Infections: From …, 2017 - Springer
We have described the radiochemical methods to produce radiopharmaceuticals for SPECT
and PET and also discussed the synthesis of several agents used for infection imaging. …

[CITATION][C] The synthesis of substituted phenylpyrimidines via Suzuki coupling reactions

…, JM Schomaker, AS Kalinda - Journal of heterocyclic …, 2006 - Wiley Online Library
This paper describes the mon‐, di‐, and triarylation of the pyrimidine ring. It is possible to
introduce one or more aryl rings in generally good yields and in a specific order, namely first in …

[CITATION][C] Pyrazinamide: a frontline drug used for tuberculosis. Molecular mechanism of action resolved after 50 years?

AS Kalinda, CC Aldrich - ChemMedChem, 2012 - Wiley Online Library
Tuberculosis (TB) is a highly contagious bacterial infection caused by Mycobacterium
tuberculosis (Mtb). Approximately nine million people develop TB every year, resulting in nearly …

The Anti-infective and Anti-cancer Properties of Artemisinin and its Derivatives

CP Hencken, AS Kalinda, JG D'Angelo - Annual Reports in Medicinal …, 2009 - Elsevier
Publisher Summary Artemisinin—a 1,2,4-trioxane sesquiterpene lactone with an atypical
endoperoxide moiety—is found to be active against the deadly cerebral form of malaria, …