Cell-programmed nutrient partitioning in the tumour microenvironment

…, JE Bader, AR Patterson, A Sugiura, AS Cohen… - Nature, 2021 - nature.com
Cancer cells characteristically consume glucose through Warburg metabolism 1 , a process
that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-…

Real-time bioluminescence imaging of glycans on live cells

AS Cohen, EA Dubikovskaya, JS Rush… - Journal of the …, 2010 - ACS Publications
Cell-surface glycans are attractive targets for molecule imaging due to their reflection of
cellular processes associated with development and disease progression. In this paper, we …

[HTML][HTML] The role of tumor tissue architecture in treatment penetration and efficacy: an integrative study

KA Rejniak, V Estrella, T Chen, AS Cohen… - Frontiers in …, 2013 - frontiersin.org
Despite the great progress that has been made in understanding cancer biology and the
potential molecular targets for its treatment, the majority of drugs fail in the clinical trials. This …

Real-Time Noninvasive Imaging of Fatty Acid Uptake in Vivo

AH Henkin, AS Cohen, EA Dubikovskaya… - ACS chemical …, 2012 - ACS Publications
Detection and quantification of fatty acid fluxes in animal model systems following physiological,
pathological, or pharmacological challenges is key to our understanding of complex …

High-throughput sequencing of peptoids and peptide− peptoid hybrids by partial Edman degradation and mass spectrometry

A Thakkar, AS Cohen, MD Connolly… - Journal of …, 2009 - ACS Publications
A method for the rapid sequence determination of peptoids [oligo(N-substituted glycines)]
and peptide−peptoid hybrids selected from one-bead-one-compound combinatorial libraries …

[HTML][HTML] Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer

AS Cohen, L Geng, P Zhao, A Fu, ML Schulte… - Translational …, 2020 - Elsevier
… Author links open overlay panel Allison S. Cohen a b , Ling Geng a b , Ping Zhao a b ,
Allie Fu a b , Michael L. Schulte a b c 1 , Ramona Graves-Deal d e , M. Kay Washington f g , …

[HTML][HTML] Cell-surface marker discovery for lung cancer

AS Cohen, FK Khalil, EA Welsh, MB Schabath… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer deaths in the United States. Novel lung cancer
targeted therapeutic and molecular imaging agents are needed to improve outcomes and …

First-in-human PET imaging and estimated radiation dosimetry of L-[5-11C]-glutamine in patients with metastatic colorectal cancer

AS Cohen, J Grudzinski, GT Smith… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Altered metabolism is a hallmark of cancer. In addition to glucose, glutamine is an important
nutrient for cellular growth and proliferation. Noninvasive imaging via PET may help …

[HTML][HTML] An online repository for pre-clinical imaging protocols (PIPs)

ST Gammon, AS Cohen, AL Lehnert, DC Sullivan… - Tomography, 2023 - mdpi.com
Providing method descriptions that are more detailed than currently available in typical peer
reviewed journals has been identified as an actionable area for improvement. In the …

[HTML][HTML] Feasibility of [18F]FSPG PET for Early Response Assessment to Combined Blockade of EGFR and Glutamine Metabolism in Wild-Type KRAS Colorectal …

SW Bae, J Wang, DK Georgiou, X Wen, AS Cohen… - Tomography, 2023 - mdpi.com
Early response assessment is critical for personalizing cancer therapy. Emerging therapeutic
regimens with encouraging results in the wild-type (WT) KRAS colorectal cancer (CRC) …