[PDF][PDF] Acetate dependence of tumors
…, L Cai, AK Witkiewicz, H Walters, MN Tantawy, A Fu… - Cell, 2014 - cell.com
Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics,
cell proliferation, and the regulation of gene expression. Highly glycolytic or hypoxic …
cell proliferation, and the regulation of gene expression. Highly glycolytic or hypoxic …
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
ML Schulte, A Fu, P Zhao, J Li, L Geng, ST Smith… - Nature medicine, 2018 - nature.com
The unique metabolic demands of cancer cells underscore potentially fruitful opportunities
for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer …
for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer …
Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation
EM Yazlovitskaya, E Edwards, D Thotala, A Fu… - Cancer research, 2006 - AACR
Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong
neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-…
neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation-…
Histone deacetylase (HDAC) inhibitor LBH589 increases duration of γ-H2AX Foci and confines HDAC4 to the cytoplasm in irradiated non–small cell lung cancer
Histone deacetylases (HDAC) have been identified as therapeutic targets due to their regulatory
function in DNA structure and organization. LBH589 is a novel inhibitor of class I and II …
function in DNA structure and organization. LBH589 is a novel inhibitor of class I and II …
The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing …
KL Osusky, DE Hallahan, A Fu, F Ye, Y Shyr, L Geng - Angiogenesis, 2004 - Springer
Antiangiogenic agents produce regression in few tumors in clinical trials, but are effective in
preventing recurrences. To determine whether the vascular endothelial growth factor (VEGF) …
preventing recurrences. To determine whether the vascular endothelial growth factor (VEGF) …
Radiation induces an antitumour immune response to mouse melanoma
CA Perez, A Fu, H Onishko, DE Hallahan… - International journal of …, 2009 - Taylor & Francis
Purpose: Irradiation of cancer cells can cause immunogenic death. We used mouse models
to determine whether irradiation of melanoma can enhance the host antitumour immune …
to determine whether irradiation of melanoma can enhance the host antitumour immune …
SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation
KC Cuneo, L Geng, A Fu, D Orton, DE Hallahan… - International Journal of …, 2008 - Elsevier
PURPOSE: SU11248 (sunitinib) is a small-molecule tyrosine kinase inhibitor which targets
VEGFR and PDGFR isoforms. In the present study, the effects of SU11248 and ionizing …
VEGFR and PDGFR isoforms. In the present study, the effects of SU11248 and ionizing …
Quantitative preclinical imaging of TSPO expression in glioma using N, N-diethyl-2-(2-(4-(2-18F-fluoroethoxy) phenyl)-5, 7-dimethylpyrazolo [1, 5-a] pyrimidin-3-yl) …
There is a critical need to develop and rigorously validate molecular imaging biomarkers to
aid diagnosis and characterization of primary brain tumors. Elevated expression of …
aid diagnosis and characterization of primary brain tumors. Elevated expression of …
Noninvasive assessment of cancer response to therapy
Rapid assessment of cancer response to a therapeutic regimen can determine efficacy
early in the course of treatment. Although biopsies of cancer can be used to rapidly assess …
early in the course of treatment. Although biopsies of cancer can be used to rapidly assess …
[HTML][HTML] Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer
AS Cohen, L Geng, P Zhao, A Fu, ML Schulte… - Translational …, 2020 - Elsevier
Improving response to epidermal growth factor receptor (EGFR)-targeted therapies in patients
with advanced wild-type (WT) RAS colorectal cancer (CRC) remains an unmet need. In …
with advanced wild-type (WT) RAS colorectal cancer (CRC) remains an unmet need. In …