Because a correlation between tau pathology and the clinical symptoms of Alzheimer disease
(AD) has been hypothesized, there is increasing interest in developing PET tracers that …

Introduction Development of a selective and specific high affinity PET tracer, [ 11 C]UCB-A,
for the in vivo study of SV2A expression in humans. Radiochemistry and preclinical studies in …

Isotopes are of immense importance in the elucidation of reaction mechanisms as tracers
and through their influence on reaction rates.’Kinetic isotope effects are used for determining …

Cleavage of the anion of 1-phenylcylopropanol to 1-phenylpropanone in aqueous solution,
a reverse aldol-type reac-tion, is subject to general acid catalysis by protonated tertiary …

Phosphodiesterase 10A (PDE10A) plays a key role in the regulation of brain striatal signaling,
and several pharmaceutical companies currently investigate PDE10A inhibitors in clinical …

Solvolytic elimination is often defined as elimination that is promoted (induced) by the
solvent (SOH), ie, the solvent acts as the hydron-abstracting base.'This review will discuss …

Affibody molecules are a class of affinity agents for molecular imaging based on a non-immunoglobulin
protein scaffold. Previous studies have demonstrated high contrast for in vivo …

The base-promoted elimination of HC1 from 9-(2-chloro-2-propyl) fluorene (2-C1) exhibits a
kinetic deuteriumisotope effect that varies with base strength and solvent character, from a …

The chlorine leaving group isotope effect has been measured for the base-promoted elimination
reaction of 1-(2-chloro-2-propyl)indene (1-Cl) in methanol at 30 C: k 35 /k 37 = 1.0086 ± …

Solvolysis of 9-(N-chloro-N-methylamino)fluorene (1-Cl) in 25 vol % acetonitrile in water
gives the imine fluorenylidenemethylamine (3) as the sole product. The kinetic deuterium …