User profiles for Alexandre Pichard
 | Alexandre PichardChief Technology Officer, Carnegie Clean Energy Verified email at carnegiece.com Cited by 80 |
Localized irradiation of cell membrane by auger electrons is cytotoxic through oxidative stress-mediated nontargeted effects
…, R Ladjohounlou, C Lozza, A Pichard… - Antioxidants & redox …, 2016 - liebertpub.com
Aims: We investigated whether radiation-induced nontargeted effects are involved in the
cytotoxic effects of anticell surface monoclonal antibodies labeled with Auger electron emitters, …
cytotoxic effects of anticell surface monoclonal antibodies labeled with Auger electron emitters, …
[HTML][HTML] Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies
…, O Achour, I Fruitier-Arnaudin, A Pichard… - … for Immunotherapy of …, 2019 - Springer
Background Triple-negative breast cancer (TNBC) treatment is currently restricted to
chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic strategies for …
chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic strategies for …
From the target cell theory to a more integrated view of radiobiology in Targeted radionuclide therapy: The Montpellier group's experience
…, B Piron, S Paillas, R Ladjohounlou, A Pichard… - Nuclear medicine and …, 2022 - Elsevier
Targeted radionuclide therapy (TRT) is used to treat disseminated or metastatic tumours in
which conventional external beam radiotherapy (EBRT) would have unacceptable side effects…
which conventional external beam radiotherapy (EBRT) would have unacceptable side effects…
Multi-agent reinforcement learning controller to maximize energy efficiency for multi-generator industrial wave energy converter
Waves in the oceans are one of the most significant renewable energy sources and are an
excellent resource to tackle climate challenges through decarbonizing energy generation. …
excellent resource to tackle climate challenges through decarbonizing energy generation. …
Skip training for multi-agent reinforcement learning controller for industrial wave energy converters
Recent Wave Energy Converters (WEC) are equipped with multiple legs and generators to
maximize energy generation. Traditional controllers have shown limitations to capture …
maximize energy generation. Traditional controllers have shown limitations to capture …
[HTML][HTML] Targeted radionuclide therapy using auger electron emitters: the quest for the right vector and the right radionuclide
Auger electron emitters (AEEs) are attractive tools in targeted radionuclide therapy to
specifically irradiate tumour cells while sparing healthy tissues. However, because of their short …
specifically irradiate tumour cells while sparing healthy tissues. However, because of their short …
Drugs that modify cholesterol metabolism alter the p38/JNK-mediated targeted and nontargeted response to alpha and auger radioimmunotherapy
R Ladjohounlou, C Lozza, A Pichard, J Constanzo… - Clinical Cancer …, 2019 - AACR
Purpose: For the development of new anticancer therapeutic radiopharmaceuticals, including
alpha particle emitters, it is important to determine the contribution of targeted effects in …
alpha particle emitters, it is important to determine the contribution of targeted effects in …
Function approximation for reinforcement learning controller for energy from spread waves
The industrial multi-generator Wave Energy Converters (WEC) must handle multiple simultaneous
waves coming from different directions called spread waves. These complex devices …
waves coming from different directions called spread waves. These complex devices …
[HTML][HTML] Targeted cancer therapy with a novel anti-CD37 beta-particle emitting radioimmunoconjugate for treatment of non-Hodgkin lymphoma
…, S Patzke, KG Fleten, D Didierlaurent, A Pichard… - PLoS …, 2015 - journals.plos.org
177 Lu-DOTA-HH1 ( 177 Lu-HH1) is a novel anti-CD37 radioimmunoconjugate developed
to treat non-Hodgkin lymphoma. Mice with subcutaneous Ramos xenografts were treated …
to treat non-Hodgkin lymphoma. Mice with subcutaneous Ramos xenografts were treated …
[HTML][HTML] Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer
…, S Besse, O Bawa, A Briat, M Quintana, A Pichard… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Tetraspanin 8 (TSPAN8) overexpression is correlated with poor prognosis in human colorectal
cancer (CRC). A murine mAb Ts29. 2 specific for human TSPAN8 provided significant …
cancer (CRC). A murine mAb Ts29. 2 specific for human TSPAN8 provided significant …