Allosteric signaling in proteins requires long-range communication mediated by highly
conserved residues, often triggered by ligand binding. In this article, we map the allosteric …

There is a need for in vivo diagnostic imaging probes that can noninvasively measure tumor-infiltrating
CD8+ leukocytes. Such imaging probes could be used to predict early response …

Phospholamban is an integral membrane protein that regulates the contractility of cardiac
muscle by maintaining cardiomyocyte calcium homeostasis. Abnormalities in association of …

Monitoring the pharmacodynamic activity of cancer immunotherapy with novel molecular
imaging tools such as 89 Zr-Df-IAB22M2C for PET imaging is of prime importance to identify …

Sarcolipin (SLN) is a 31 amino acid integral membrane protein that regulates Ca-ATPase
activity in skeletal muscle. Here, we report the three-dimensional structure and topology of …

LP2086 is a family of outer membrane lipoproteins from Neisseria meningitidis, which elicits
bactericidal antibodies and are currently undergoing human clinical trials in a bivalent …

Fibroblast activation protein (FAP), expressed on cancer-associated fibroblasts, is a target
for diagnosis and therapy in multiple tumour types. Strategies to systemically deplete FAP-…

Human islet amyloid polypeptide (hIAPP), or amylin, is a 37 amino acid hormone secreted
by pancreatic β‐cells. hIAPP constitutes ∼90% of the amyloid deposits found in type II …

Solid-state NMR spectroscopy, in conjunction with rigid body molecular dynamics calculations,
shows that monomeric phospholamban in lipid bilayers has two distinct helical domains, …

Organotin compounds or alkyltins are ubiquitous environmental toxins that have been
implicated in cellular death. Unlike other xenobiotic compounds, such as organomercurials and …