Fluorine-containing nucleoside analogs (NAs) represent a significant class of the US FDA-approved
chemotherapeutics widely used in the clinic. The incorporation of fluorine into drug-…

Recent findings suggest that β-amyloid (Aβ) is more neurotoxic when present in its oligomeric
configuration rather than as monomers or fibrils. Previous work from our laboratories has …

Pseudomonas aeruginosa plays a major role in many chronic infections. Its ability to readily
form biofilms contributes to its success as an opportunistic pathogen and its resistance/…

The morbidity associated with pediatric medulloblastoma, in particular in patients who
develop leptomeningeal metastases, remains high in the absence of effective therapies. …

Background Amivantamab is a novel bispecific antibody that simultaneously targets the
epidermal growth factor receptor (EGFR) and the hepatocyte growth factor receptor (HGFR/c-…

A new series of oxadiazoles were designed to act as inhibitors of the anti‐apoptotic Bcl‐2
protein. Virtual screening led to the discovery of new hits that interact with Bcl‐2 at the BH 3 …

Breast cancer is the most common cancer in women worldwide. The heterogeneity of breast
cancer and drug resistance to therapies make the diagnosis and treatment difficult. …

There is a need for prognostic markers to select patients most likely to benefit from antibody–drug
conjugate (ADC) therapy. We quantified the relationship between pretreatment PET …

Simple Summary Different combination therapies are being investigated for the treatment of
triple-negative breast cancer (TNBC). Dasatinib is one such drug that targets the Src …

Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and
anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and …