[HTML][HTML] A picture of modern Tc-99m radiopharmaceuticals: Production, chemistry, and applications in molecular imaging

A Boschi, L Uccelli, P Martini - Applied Sciences, 2019 - mdpi.com
Even today, techentium-99m represents the radionuclide of choice for diagnostic radio-imaging
applications. Its peculiar physical and chemical properties make it particularly suitable …

The emerging role of copper-64 radiopharmaceuticals as cancer theranostics

A Boschi, P Martini, E Janevik-Ivanovska, A Duatti - Drug Discovery Today, 2018 - Elsevier
Highlights • Copper radionuclides for in vivo imaging of biological functions of copper ions. •
Copper-64 has suitable nuclear properties for cancer theranostics. • Radioactive copper …

Chemistry of the Strong Electrophilic Metal Fragment [99Tc(N)(PXP)]2+ (PXP = Diphosphine Ligand). A Novel Tool for the Selective Labeling of Small Molecules

C Bolzati, A Boschi, L Uccelli, F Tisato… - Journal of the …, 2002 - ACS Publications
Monosubstituted [M(N)Cl 2 (POP)] [M = Tc, 1; Re, 2] and [M(N)Cl 2 (PNP)] [M = Tc, 3; Re, 4]
complexes were prepared by reaction of the precursors [M(N)Cl 4 ] - and [M(N)Cl 2 (PPh 3 ) 2 …

Synthesis and biologic evaluation of monocationic asymmetric 99mTc-nitride heterocomplexes showing high heart uptake and improved imaging properties

A Boschi, L Uccelli, C Bolzati, A Duatti… - Journal of Nuclear …, 2003 - Soc Nuclear Med
The preparation, characterization, and first biologic evaluation in rats of a novel class of
monocationic 99m Tc heart imaging agents are reported. The complexes are represented by the …

Wet spinning of Bombyx mori silk fibroin dissolved in N-methyl morpholine N-oxide and properties of regenerated fibres

E Marsano, P Corsini, C Arosio, A Boschi… - International Journal of …, 2005 - Elsevier
Silk fibroin (SF) was dissolved in N-methyl morpholine N-oxide (NMMO) at a polymer
concentration of 13% (w/w); thermal and rheological solution properties were characterized. The …

Oldie but goodie: Is technetium-99m still a treasure trove of innovation for medicine? A Patents Analysis (2000–2022)

…, P Martini, C Cittanti, A Boschi… - Journal of Medicinal …, 2023 - ACS Publications
Technetium-99m is the workhorse of diagnostic nuclear medicine. The aim of the work is to
analyze the technetium-99m patents since 2000 to photograph its innovation. QUESTEL’s …

Recent achievements in Tc-99m radiopharmaceutical direct production by medical cyclotrons

A Boschi, P Martini, M Pasquali… - Drug development and …, 2017 - Taylor & Francis
99m Tc is the most commonly used radionuclide in the field of diagnostic imaging, a
noninvasive method intended to diagnose a disease, assess the disease state and monitor the …

In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals

P Martini, A Boschi, G Cicoria, F Zagni… - Applied Radiation and …, 2018 - Elsevier
In the last years, the technology for producing the important medical radionuclide technetium-99m
by cyclotrons has become sufficiently mature to justify its introduction as an alternative …

A kit formulation for the preparation of 188Re-lipiodol: preclinical studies and preliminary therapeutic evaluation in patients with unresectable hepatocellular …

A Boschi, L Uccelli, A Duatti, P Colamussi… - Nuclear Medicine …, 2004 - journals.lww.com
A lyophilized kit formulation for the efficient labelling of lipiodol with generator-produced
rhenium-188 is described. The preliminary preparation of the lipophilic complex bis-(…

[HTML][HTML] Technetium-99m radiopharmaceuticals for ideal myocardial perfusion imaging: Lost and found opportunities

A Boschi, L Uccelli, L Marvelli, C Cittanti, M Giganti… - Molecules, 2022 - mdpi.com
The favorable nuclear properties in combination with the rich coordination chemistry make
technetium-99m the radioisotope of choice for the development of myocardial perfusion …