The pancreas cancer microenvironment
C Feig, A Gopinathan, A Neesse, DS Chan, N Cook… - Clinical cancer …, 2012 - AACR
Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in
more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and …
more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and …
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
MA Jacobetz, DS Chan, A Neesse, TE Bapiro, N Cook… - Gut, 2013 - gut.bmj.com
Objective Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia
and vascular dysfunction, which critically impair drug delivery. This study examines the role …
and vascular dysfunction, which critically impair drug delivery. This study examines the role …
Stromal biology and therapy in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is an almost uniformly lethal disease. One
explanation for the devastating prognosis is the failure of many chemotherapies, including the …
explanation for the devastating prognosis is the failure of many chemotherapies, including the …
Stromal biology and therapy in pancreatic cancer: a changing paradigm
A Neesse, H Algül, DA Tuveson, TM Gress - Gut, 2015 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid
tumours and poses an unsolved problem in cancer medicine. Despite the recent success of …
tumours and poses an unsolved problem in cancer medicine. Despite the recent success of …
nab-Paclitaxel Potentiates Gemcitabine Activity by Reducing Cytidine Deaminase Levels in a Mouse Model of Pancreatic Cancer
KK Frese, A Neesse, N Cook, TE Bapiro, MP Lolkema… - Cancer discovery, 2012 - AACR
Nanoparticle albumin-bound (nab)-paclitaxel, an albumin-stabilized paclitaxel formulation,
demonstrates clinical activity when administered in combination with gemcitabine in patients …
demonstrates clinical activity when administered in combination with gemcitabine in patients …
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
A Neesse, CA Bauer, D Öhlund, M Lauth, M Buchholz… - Gut, 2019 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …
CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
A Neesse, KK Frese, TE Bapiro… - Proceedings of the …, 2013 - National Acad Sciences
Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant desmoplasia and
poor tissue perfusion. These features are proposed to limit the access of therapies to …
poor tissue perfusion. These features are proposed to limit the access of therapies to …
Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated …
…, A Campbell, C Doglioni, D Jodrell, A Neesse… - Gastroenterology, 2016 - Elsevier
Background & Aims One treatment strategy for pancreatic ductal adenocarcinoma is to modify,
rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and …
rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and …
[HTML][HTML] Microenvironmental determinants of pancreatic cancer
…, TM Gress, V Ellenrieder, A Neesse - Physiological …, 2020 - journals.physiology.org
Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in humans.
A histological hallmark feature of PDAC is the pronounced tumor microenvironment (TME) …
A histological hallmark feature of PDAC is the pronounced tumor microenvironment (TME) …
Management of severe acute pancreatitis: an update
…, C Ammer-Herrmenau, V Ellenrieder, A Neesse - Digestion, 2021 - karger.com
Background: Severe acute pancreatitis (AP) continues to be a serious gastrointestinal disease
with relevant morbidity and mortality. Summary: Successful clinical management requires …
with relevant morbidity and mortality. Summary: Successful clinical management requires …