Purpose Because current approaches to risk classification and treatment stratification for
children with neuroblastoma (NB) vary greatly throughout the world, it is difficult to directly …

Background Immunotherapy with the chimeric anti-GD2 monoclonal antibody dinutuximab,
combined with alternating granulocyte-macrophage colony-stimulating factor and …

Background High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free
survival in patients with high-risk neuroblastoma; however, which regimen has the …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase predominantly expressed
in the developing nervous system. Recently, mutated ALK has been identified as a major …

Perforin mutations have been demonstrated in a proportion of patients diagnosed with the
familial form of hemophagocytic lymphohistiocytosis (HLH). In the present study, we evaluated …

Lymphomas account for 10%–15% of all childhood cancers and include a number of different
pathologic subtypes, which arise from the constituent cells of the immune system or from …

Purpose: To compare the outcomes associated with modifications in three consecutive
protocols employed by the Italian Co-Operative Group for Neuroblastoma (ICGNB) in …

PURPOSE: To report on the treatment of patients with newly diagnosed neuroblastoma
presenting with spinal cord compression (SCC). PATIENTS AND METHODS: Of 1,462 children …

Purpose: Fenretinide (4HPR), a synthetic retinoid, induces apoptosis in neuroblastoma cells.
A Phase I study in children with neuroblastoma was designed to determine maximum …

Purpose To review a historical cohort of childhood ganglioneuroma (GN), the benign
representative of the peripheral neuroblastic tumor (PNT) family. Patients and Methods Of 2,286 …