Restoration of brain circulation and cellular functions hours post-mortem

…, N Kaur, ZW Zhuang, Z Liu, R Alkawadri, AJ Sinusas… - Nature, 2019 - nature.com
The brains of humans and other mammals are highly vulnerable to interruptions in blood
flow and decreases in oxygen levels. Here we describe the restoration and maintenance of …

[HTML][HTML] Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction

…, JA Madri, BL Zaret, AJ Sinusas - The Journal of …, 2004 - Am Soc Clin Investig
Noninvasive imaging strategies will be critical for defining the temporal characteristics of
angiogenesis and assessing efficacy of angiogenic therapies. The αvβ3 integrin is expressed in …

[HTML][HTML] Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel

…, R Sawh-Martinez, JK Harrington, A Sinusas… - The FASEB …, 2011 - ncbi.nlm.nih.gov
We developed a tissue-engineered vascular graft composed of biodegradable scaffold
seeded with autologous bone marrow-derived mononuclear cells (BMMCs) that is currently in …

Estimation of 3-D left ventricular deformation from medical images using biomechanical models

X Papademetris, AJ Sinusas, DP Dione… - IEEE transactions on …, 2002 - ieeexplore.ieee.org
The quantitative estimation of regional cardiac deformation from three-dimensional (3-D)
image sequences has important clinical implications for the assessment of viability in the heart …

Deep learning for prediction of obstructive disease from fast myocardial perfusion SPECT: a multicenter study

…, MB Fish, TD Ruddy, P Kaufmann, AJ Sinusas… - JACC: Cardiovascular …, 2018 - jacc.org
Objectives : The study evaluated the automatic prediction of obstructive disease from myocardial
perfusion imaging (MPI) by deep learning as compared with total perfusion deficit (TPD)…

Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo

…, X Hu, M Caplan, J Ren, GI Shulman, AJ Sinusas - Circulation, 1997 - Am Heart Assoc
Background Myocardial ischemia increases heart glucose utilization in vivo. However, whether
low-flow ischemia leads to the translocation of glucose transporter (GLUT)-4 and/or GLUT…

Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction

…, C MacGillivray, RT Lee, AJ Sinusas… - American Journal …, 2006 - journals.physiology.org
Matrix metalloproteinases (MMPs) are postulated to be necessary for neovascularization
during wound healing. MMP-9 deletion alters remodeling postmyocardial infarction (post-MI), …

Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model

…, TL Mirensky, T Yi, TF Hazlett, G Tellides, AJ Sinusas… - Biomaterials, 2008 - Elsevier
The development of neotissue in tissue engineered vascular grafts remains poorly understood.
Advances in mouse genetic models have been highly informative in the study of vascular …

Estimation of 3D left ventricular deformation from echocardiography

X Papademetris, AJ Sinusas, DP Dione… - Medical image …, 2001 - Elsevier
The quantitative estimation of regional cardiac deformation from 3D image sequences has
important clinical implications for the assessment of viability in the heart wall. Such estimates …

Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling

…, S Robinson, DS Edwards, AJ Sinusas - Circulation, 2005 - Am Heart Assoc
… Drs Spinale and Sinusas have sponsored research agreements with Bristol-Myers Squibb
Medical Imaging, North Billerica, Mass. Drs Azure, Yalamanchili, Liu, Cheesman, Robinson, …