Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells

…, A Patel, RE Mansel, I Neeman, AA Geldof… - Journal of medicinal …, 2004 - liebertpub.com
We completed a multicenter study of the effects of pomegranate cold-pressed (Oil) or
supercritical CO 2 -extracted (S) seed oil, fermented juice polyphenols (W), and pericarp …

Effect of age on functional P‐glycoprotein in the blood‐brain barrier measured by use of (R)‐[11C]verapamil and positron emission tomography

…, G Luurtsema, M Lubberink, AA Geldof… - Clinical …, 2006 - Wiley Online Library
Introduction P‐glycoprotein (P‐gp) is an efflux transporter responsible for the transport of
various drugs across the blood‐brain barrier (BBB). Loss of P‐gp function with age may be one …

Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients

IV Bijnsdorp, AA Geldof, M Lavaei… - Journal of …, 2013 - Taylor & Francis
Background Cancer cells are able to change the protein expression and behavior of non-cancerous
surrounding cells. Exosomes, secreted by prostate cancer (PCa) cells, may have a …

[HTML][HTML] Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis

…, MP van den Tol, HMW Verheul, AA Geldof… - British journal of …, 2013 - nature.com
Background: Five-year survival after resection of colorectal cancer liver metastasis (CRLCM)
is< 30%. We recently found that aurora kinase A (AURKA) drives 20q gain-associated …

Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays

AA Geldof, SC Mastbergen, REC Henrar… - Cancer chemotherapy …, 1999 - Springer
Purpose: New classes of anticancer drugs, isolated from marine organisms, have been
shown to possess cytotoxic activity against multiple tumor types. Aplidine, didemnin B, and …

Protein complexes in urine interfere with extracellular vesicle biomarker studies

…, M Pegtel, AA Geldof… - Journal of …, 2016 - journals.sagepub.com
Urine exosomes (extracellular vesicles; EVs) contain (micro)RNA (miRNA) and protein
biomarkers that are useful for the non-invasive diagnosis of various urological diseases. However…

Models for cancer skeletal metastasis: a reappraisal of Batson's plexus.

AA Geldof - Anticancer research, 1997 - europepmc.org
While skeletal metastasis in prostate cancer is a major and frequent complication, literature
data on the mechanisms involved are quite confusing. Recent efforts, however, to establish …

Glucose transporter 1 (SLC2A1) and vascular endothelial growth factor A (VEGFA) predict survival after resection of colorectal cancer liver metastasis

…, CW Menke-Van der Houven, AA Geldof… - Annals of …, 2016 - journals.lww.com
Objective: To investigate the individual and combined prognostic value of HIF1 α, SLC2A1,
and vascular endothelial growth factor A (VEGFA) in a multi-institutional cohort of patients …

ABCC4 Decreases docetaxel and not cabazitaxel efficacy in prostate cancer cells in vitro

…, OS Hoekstra, AA Geldof - Anticancer …, 2013 - ar.iiarjournals.org
Background: This study aimed to investigate cabazitaxel efficacy in a model for docetaxel-resistant
prostate cancer cells and to evaluate the involvement of ATP-cassette binding protein …

Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells

AA Geldof, MAT De Kleijn, B Ramanath Rao… - Journal of cancer …, 1997 - Springer
The prevalence of nerve growth factor (NGF) production in different human prostatic tumor
cell lines (DU145, PC-3, LNCaP-FGC) was investigated using a specific enzyme-linked …