Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction

…, J Zhou, B Arbo, A Rogstad, A Cuthbertson… - Journal of the American …, 2008 - jacc.org
Objectives : The purpose of this study was to evaluate interstitial alterations in myocardial
remodeling using a radiolabeled Cy5.5-RGD imaging peptide (CRIP) that targets …

One Step Radiosynthesis of 6-[18F]Fluoronicotinic Acid 2,3,5,6-Tetrafluorophenyl Ester ([18F]F-Py-TFP): A New Prosthetic Group for Efficient Labeling of …

…, GM Kindberg, A Cuthbertson - Journal of medicinal …, 2010 - ACS Publications
The labeling of biomolecules for positron emission tomography (PET) with no-carrier-added
fluorine-18 is almost exclusively accomplished using prosthetic groups in a two step …

Preclinical efficacy of a PSMA-targeted thorium-227 conjugate (PSMA-TTC), a targeted alpha therapy for prostate cancer

…, J Karlsson, RM Bjerke, OB Ryan, AS Cuthbertson… - Clinical Cancer …, 2020 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) is an attractive target for radionuclide
therapy of metastatic castration-resistant prostate cancer (mCRPC). PSMA-targeted alpha …

Mesothelin-targeted thorium-227 conjugate (MSLN-TTC): preclinical evaluation of a new targeted alpha therapy for mesothelin-positive cancers

…, D Mumberg, K Ziegelbauer, AS Cuthbertson - Clinical Cancer …, 2019 - AACR
Purpose: Targeted thorium-227 conjugates (TTC) represent a new class of molecules for
targeted alpha therapy (TAT). Covalent attachment of a 3,2-HOPO chelator to an antibody …

In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia

…, RM Bjerke, OB Ryan, AS Cuthbertson - Molecular cancer …, 2016 - AACR
The clinical efficacy of the first approved alpha pharmaceutical, Xofigo (radium-223
dichloride, 223 RaCl 2 ), has stimulated significant interest in the development of new alpha-particle …

Evaluation of new occult blood tests for detection of colorectal neoplasia

…, MA Alexeyeff, MC Deacon, AM Cuthbertson… - Gastroenterology, 1993 - Elsevier
Background: Hemoccult II, the guaiac-based fecal occult blood test used in most colorectal
cancer screening programs, has an unsatisfactory sensitivity for asymptomatic colorectal …

Radiosynthesis and Biodistribution of Cyclic RGD Peptides Conjugated with Novel [18F]Fluorinated Aldehyde-Containing Prosthetic Groups

…, S Champion, GM Kindberg, A Cuthbertson - Bioconjugate …, 2008 - ACS Publications
Achieving high-yielding, robust, and reproducible chemistry is a prerequisite for the 18 F-labeling
of peptides for quantitative receptor imaging using positron emission tomography (PET)…

[HTML][HTML] An efficient chelator for complexation of thorium-227

…, RM Bjerke, D Grant, EM Brevik, AS Cuthbertson - Bioorganic & Medicinal …, 2016 - Elsevier
We present the synthesis and characterization of a highly efficient thorium chelator, derived
from the octadentate hydroxypyridinone class of compounds. The chelator forms extremely …

Advances in precision oncology: targeted thorium-227 conjugates as a new modality in targeted alpha therapy

…, H Hennekes, D Mumberg, AS Cuthbertson - Cancer Biotherapy & …, 2020 - liebertpub.com
Targeted α therapy (TAT) offers the potential for the targeted delivery of potent α-particle-emitting
radionuclides that emit high linear energy transfer radiation. This leads to a densely …

[HTML][HTML] Immunostimulatory effects of targeted thorium-227 conjugates as single agent and in combination with anti-PD-L1 therapy

…, H Hennekes, J Karlsson, AS Cuthbertson… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Targeted thorium-227 conjugates (TTCs) are an emerging class of targeted
alpha therapies (TATs). Their unique mode of action (MoA) is the induction of difficult-to-repair …