User profiles for Alain C. Colige

Alain Colige

Laboratory of Connective Tissue Biology, GIGA, University of Liege, Belgium
Verified email at uliege.be
Cited by 9682

[HTML][HTML] Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the …

BV Nusgens, AC Colige, CA Lambert… - Journal of Investigative …, 2001 - Elsevier
Ascorbic acid (vitamin C) is a cofactor required for the function of several hydroxylases and
monooxygenases. It is not synthesized in humans and some other animal species and has to …

[HTML][HTML] Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated …

Y Kato, CA Lambert, AC Colige, P Mineur… - Journal of Biological …, 2005 - ASBMB
The extracellular pH (pHe) of tumor tissues is often acidic, which can induce the expression
of several proteins. We previously showed that production of matrix metalloproteinase-9 (…

[HTML][HTML] Effects of mild cold shock (25 C) followed by warming up at 37 C on the cellular stress response

T Neutelings, CA Lambert, BV Nusgens, AC Colige - PloS one, 2013 - journals.plos.org
Temperature variations in cells, tissues and organs may occur in a number of circumstances.
We report here that reducing temperature of cells in culture to 25C for 5 days followed by a …

18F-FDG uptake assessed by PET/CT in abdominal aortic aneurysms is associated with cellular and molecular alterations prefacing wall deterioration and rupture

…, P Delvenne, JB Michel, AC Colige… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Rupture of abdominal aortic aneurysms (AAAs) leads to a significant morbidity and mortality
in aging populations, and its prediction would be most beneficial to public health. Spots …

Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen …

…, F Kesteloot, K Powell, DE Birk, AC Colige… - 2006 - journals.biologists.com
Mutations in ADAMTS2, a procollagen amino-propeptidase, cause severe skin fragility,
designated as dermatosparaxis in animals, and a subtype of the Ehlers-Danlos syndrome (…

Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents

P Mineur, AC Colige, CF Deroanne, J Dubail… - The Journal of cell …, 2007 - rupress.org
Ultraviolet B and genotoxic drugs induce the expression of a vascular endothelial growth factor
A (VEGF-A) splice variant (VEGF111) encoded by exons 1–4 and 8 in many cultured cells…

[HTML][HTML] Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment

L Brohée, S Demine, J Willems, T Arnould, AC Colige… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer
cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing …

[HTML][HTML] Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression

…, B Nusgens, V Castronovo, M Thiry, AC Colige… - Scientific reports, 2018 - nature.com
Propranolol, a widely used non-selective beta-adrenergic receptor blocker, was recently
shown to display anticancer properties. Its potential to synergize with certain drugs has been …

Distinct pathways in the over-expression of matrix metalloproteinases in human fibroblasts by relaxation of mechanical tension

CA Lambert, AC Colige, C Munaut, CM Lapière… - Matrix Biology, 2001 - Elsevier
The aim of the work was to analyze, on a comparative basis, the signaling pathways operating
in the regulation of a panel of matrix metalloproteinases (MMP) expressed by human …

Metallothionein-dependent up-regulation of TGF-β2 participates in the remodelling of the myxomatous mitral valve

…, MA Radermecker, AC Colige - Cardiovascular …, 2012 - academic.oup.com
Aims Although an excessive extracellular matrix remodelling has been well described in
myxomatous mitral valve (MMV), the underlying pathogenic mechanisms remain largely …