[PDF][PDF] Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase

S Jeger, K Zimmermann, A Blanc, J Grünberg… - Angew Chem Int Ed …, 2010 - academia.edu
The therapeutic efficacy of antibodies can be substantially enhanced by conjugation of cytotoxic
compounds such as chemotherapeutics and particle-emitting radionuclides.[1] Intuitively …

Future prospects for SPECT imaging using the radiolanthanide terbium-155—production and preclinical evaluation in tumor-bearing mice

…, H Dorrer, J Reber, S Haller, S Cohrs, A Blanc… - Nuclear medicine and …, 2014 - Elsevier
Introduction We assessed the suitability of the radiolanthanide 155 Tb (t 1/2 = 5.32 days, E γ
= 87 keV (32%), 105 keV (25%)) in combination with variable tumor targeted biomolecules …

High‐resolution SPECT imaging of stimuli‐responsive soft microrobots

V Iacovacci, A Blanc, H Huang, L Ricotti, R Schibli… - Small, 2019 - Wiley Online Library
Untethered small‐scale robots have great potential for biomedical applications. However,
critical barriers to effective translation of these miniaturized machines into clinical practice exist…

Preclinical evaluation of a new, stabilized neurotensin (8–13) pseudopeptide radiolabeled with 99mTc

…, P Bläuenstein, M Bruehlmeier, A Blanc… - Journal of Nuclear …, 2002 - Soc Nuclear Med
The rapid degradation of neurotensin (NT) limits its clinical use in cancer imaging and therapy.
Thus, a new NT(8–13) pseudopeptide, NT-VIII, was synthesized. Some changes were …

Chemical and biological characterization of new Re (CO) 3/[99mTc](CO) 3 bombesin analogues

…, M Zwimpfer, IU Khan, V Maes, A Blanc… - Nuclear medicine and …, 2007 - Elsevier
INTRODUCTION: Bombesin, a neuropeptide with potential for breast and prostate tumor
targeting, is rapidly metabolized in vivo, and as a result, uptake in tumor xenografts in mice is …

Dual, Site‐Specific Modification of Antibodies by Using Solid‐Phase Immobilized Microbial Transglutaminase

…, D Messmer, A Ritler, A Küchler, A Blanc… - …, 2017 - Wiley Online Library
Microbial transglutaminase (MTG) was stably solid‐phase immobilized on glass microbeads
by using a second‐generation dendronized polymer. Immobilized MTG enabled the …

A stable neurotensin-based radiopharmaceutical for targeted imaging and therapy of neurotensin receptor-positive tumours

E García-Garayoa, P Bläuenstein, A Blanc… - European journal of …, 2009 - Springer
Purpose Neurotensin (NT) and its high affinity receptor (NTR1) are involved in several
neoplastic processes. Thus, NT-based radiopharmaceuticals are potential tracers for targeted …

Stabilization of neurotensin analogues: effect on peptide catabolism, biodistribution and tumor binding

M Bruehlmeier, EG Garayoa, A Blanc, B Holzer… - Nuclear medicine and …, 2002 - Elsevier
Neurotensin (NT) receptors in pancreatic and other neuroendocrine tumors are promising
targets for imaging and therapeutic purposes. Here, we report on the effect of distinct changes …

[HTML][HTML] Evaluation of Actinium-225 Labeled Minigastrin Analogue [225Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy

Y Qin, S Imobersteg, A Blanc, S Frank, R Schibli… - Pharmaceutics, 2020 - mdpi.com
The overexpression of cholecystokinin B receptor (CCKBR) in human cancers led to the
development of radiolabeled minigastrin analogues for targeted radionuclide therapy, which …

[HTML][HTML] Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

PS Lienemann, S Metzger, AS Kiveliö, A Blanc… - Scientific reports, 2015 - nature.com
Over the last decades, great strides were made in the development of novel implants for the
treatment of bone defects. The increasing versatility and complexity of these implant designs …