User profiles for Aladar A. Szalay
Aladar A. SzalayProfessor (Biochemistry), University of Würzburg - Cancer Therapy Research Center Verified email at biozentrum.uni-wuerzburg.de Cited by 14457 |
Imaging of light emission from the expression of luciferases in living cells and organisms: a review
LF Greer III, AA Szalay - … : the journal of biological and chemical …, 2002 - Wiley Online Library
Luciferases are enzymes that emit light in the presence of oxygen and a substrate (luciferin)
and which have been used for real‐time, low‐light imaging of gene expression in cell …
and which have been used for real‐time, low‐light imaging of gene expression in cell …
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins
…, R Beltz, I Gentschev, W Goebel, AA Szalay - Nature …, 2004 - nature.com
We have shown that bacteria injected intravenously into live animals entered and replicated
in solid tumors and metastases. The tumor-specific amplification process was visualized in …
in solid tumors and metastases. The tumor-specific amplification process was visualized in …
Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus
…, RL Danner, PJ Munson, FM Marincola, AA Szalay - Cancer research, 2007 - AACR
Previously, we reported that a recombinant vaccinia virus (VACV) carrying a light-emitting
fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new …
fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new …
Tumor-specific colonization, tissue distribution, and gene induction by probiotic Escherichia coli Nissle 1917 in live mice
Systemic administration of microorganisms into tumor-bearing mice revealed preferential
accumulation in tumors in comparison to clearance in organs such as spleen and liver. Here …
accumulation in tumors in comparison to clearance in organs such as spleen and liver. Here …
Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes
Eukaryotic expression vectors can be delivered to macrophages using attenuated self-destructing
Listeria monocytogenes. L. monocytogenes cells are preferentially lysed in the host …
Listeria monocytogenes. L. monocytogenes cells are preferentially lysed in the host …
Stable integration of foreign DNA into the chromosome of the cyanobacterium Synechococcus R2
JGK Williams, AA Szalay - Gene, 1983 - Elsevier
The blue-green alga, Synechococcus R2, is transformed to antibiotic resistance by chimeric
DNA molecules consisting of Synechococcus R2 chromosomal DNA linked to antibiotic-…
DNA molecules consisting of Synechococcus R2 chromosomal DNA linked to antibiotic-…
Microinjection and growth of bacteria in the cytosol of mammalian host cells
…, M Beck, J Slaghuis, AA Szalay… - Proceedings of the …, 2001 - National Acad Sciences
Most facultative intracellular bacteria replicate in specialized phagosomes after being taken
up by mammalian cells. Relatively few intracellular bacteria escape the phagosomal …
up by mammalian cells. Relatively few intracellular bacteria escape the phagosomal …
Phase I trial of intravenous oncolytic vaccinia virus (GL-ONC1) with cisplatin and radiotherapy in patients with locoregionally advanced head and neck carcinoma
…, RA Weisman, PR Sanghvi, PJ Martin, AA Szalay - Clinical cancer …, 2017 - AACR
Purpose: Preclinical models have shown that the effectiveness of GL-ONC1, a modified
oncolytic vaccinia virus, is enhanced by radiation and chemotherapy. The purpose of this study …
oncolytic vaccinia virus, is enhanced by radiation and chemotherapy. The purpose of this study …
Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer
…, V Ntziachristos, AA Szalay - Proceedings of the …, 2013 - National Acad Sciences
We reported earlier the delivery of antiangiogenic single chain antibodies by using oncolytic
vaccinia virus strains to enhance their therapeutic efficacy. Here, we provide evidence that …
vaccinia virus strains to enhance their therapeutic efficacy. Here, we provide evidence that …
Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68
Oncolytic virotherapy of tumors has shown promising results in both preclinical and clinical
studies. Here, we investigated the therapeutic efficacy of a replication-competent vaccinia …
studies. Here, we investigated the therapeutic efficacy of a replication-competent vaccinia …