Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes
and antioxidant stress proteins in response to electrophilic agents and oxidative stress. In …

Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions
and leads to liver injury and neurodegeneration, but the details of abnormalities related to …

Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by
the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These …

Induction of a family of phase 2 genes encoding for proteins that protect against the damage
of electrophiles and reactive oxygen intermediates is potentially a major strategy for …

The Keap1-Nrf2 system is the major regulatory pathway of cytoprotective gene expression
against oxidative and/or electrophilic stresses. Keap1 acts as a stress sensor protein in this …

Nrf2 regulates the cellular oxidative stress response, whereas Keap1 represses Nrf2 through
its molecular interaction. To elucidate the molecular mechanism of the Keap1 and Nrf2 …

322 subjects participated in an experimental study to investigate the effects of tactile,
olfactory, audio and visual sensory cues on a participant's sense of presence in a virtual …

Oxidative and electrophilic stresses are sensed by Keap1, which activates Nrf2 to achieve
cytoprotection by regulating the expression of drug-metabolizing and antioxidative stress …

Transcription factor Nrf2 regulates basal and inducible expression of phase 2 proteins that
protect animal cells against the toxic effects of electrophiles and oxidants. Under basal …

Keap1 and Cul3 constitute a unique ubiquitin E3 ligase that degrades Nrf2, a key activator of
cytoprotective genes. Upon exposure to oxidants/electrophiles, the enzymatic activity of this …