User profiles for Aileen Höhne

Aileen Hoehne

3B Pharmaceuticals GmbH
Verified email at 3b-pharma.com
Cited by 1562

Synthesis, 18F-Labeling, and in Vitro and in Vivo Studies of Bombesin Peptides Modified with Silicon-Based Building Blocks

A Höhne, L Mu, M Honer, PA Schubiger… - Bioconjugate …, 2008 - ACS Publications
The gastrin-releasing peptide receptor (GRPr) is overexpressed on various human tumors.
The goal of our study was the synthesis of new 18 F-labeled bombesin analogues for the PET …

[PDF][PDF] Silicon‐Based Building Blocks for One‐Step 18F‐Radiolabeling of Peptides for PET Imaging

L Mu, A Höhne, PA Schubiger… - Angewandte Chemie …, 2008 - academia.edu
Positron emission tomography (PET) is an important diagnostic tool in modern medicine
due to its ability to locate and assess abnormalities in neurology,[1a–e] oncology,[1f–j] and …

Organofluorosilanes as Model Compounds for 18F‐Labeled Silicon‐Based PET Tracers and their Hydrolytic Stability: Experimental Data and Theoretical …

A Höhne, L Yu, L Mu, M Reiher… - … A European Journal, 2009 - Wiley Online Library
Water stable! Radiochemists have recently discovered silicon chemistry as a tool for the
introduction of 18 F into biomolecules for positron emission tomography (PET) imaging. F‐…

Proof of therapeutic efficacy of a 177Lu-labeled neurotensin receptor 1 antagonist in a colon carcinoma xenograft model

…, F Osterkamp, U Reineke, A Höhne… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Increased expression of neurotensin receptor 1 (NTR1) has been shown in a large number
of tumor entities such as pancreatic or colon carcinoma. Hence, this receptor is a promising …

[PDF][PDF] Siliciumbausteine fur eine einstufige 18F-Radiomarkierung von Peptiden fur die PET-Bildgebung

L Mu, A Hohne, PA Schubiger… - Angewandte Chemie …, 2008 - academia.edu
Die Positronenemissionstomographie (PET) ist ein wichtiges Diagnoseverfahren in der
modernen Neurologie,[1a–e] Onkologie [1f–j] und Kardiologie.[1k, l] Die Anwendung kleiner 18F-…

Synthesis of 18 F-labelled cyclooxygenase-2 (COX-2) inhibitors via Stille reaction with 4-[18 F] fluoroiodobenzene as radiotracers for positron emission tomography …

FR Wüst, A Höhne, P Metz - Organic & biomolecular chemistry, 2005 - pubs.rsc.org
The Stille reaction with 4-[18F]fluoroiodobenzene as a novel approach for the synthesis of
radiotracers for monitoring COX-2 expression by means of PET has been developed. …

Fibroblast activation protein (FAP)-targeted radiotherapy increases tumor CD8+ T cell infiltration and enhances response to PD-1 immune checkpoint blockade

D Zboralski, A Höhne, E Christensen, M Paschke… - Cancer Research, 2023 - AACR
Background: FAP is a membrane-bound protease under investigation as a pan-cancer target,
given its high expression in tumors but limited expression in normal tissues. FAP-2286 is a …

[PDF][PDF] Development of new silicon-based building blocks for a direct ¹⁸F-labeling of biomolecules for PET imaging

A Höhne - 2008 - research-collection.ethz.ch
Die Positronen-Emissions-Tomographie (PET) ist ein nicht-invasives nuklearmedizinisches
Verfahren zur Untersuchung biochemischer und physiologischer Prozesse in vivo. Es …

[PDF][PDF] Development of new nucleoside analogues as PET imaging agents for monitoring gene expression

M Martić - 2008 - research-collection.ethz.ch
Aileen Höhne, a “personal secretary”, without whom I would be lost in schedule. Thank
you for the friendship and those 3 nice years in the lab ☺ … Dr. Jessica Becaud for the nice …

[CITATION][C] Silicon-Based Building Blocks for One-Step ¹⁸F-Radiolabeling of Peptides for PET Imaging

L Mu, A Höhne, P Schubiger, SM Ametamey, K Graham… - Angewandte Chemie, 2008