Nuclear hormone receptors (NHRs) are transcription factors that work in concert with co-activators
and co-repressors to regulate gene expression. Some examples of ligands for NHRs …

Hypermethylation of CpG islands in the promoter regions is an important mechanism to
silence the expression of many important genes in cancer. The hypermethylation status is …

Purpose Treatment of advanced non–small-cell lung cancer with immune checkpoint inhibitors
(ICIs) is characterized by durable responses and improved survival in a subset of patients…

Combination immune checkpoint blockade has demonstrated promising benefit in lung
cancer, but predictors of response to combination therapy are unknown. Using whole-exome …

Purpose Human epidermal growth factor receptor 2 (HER2, ERBB2)–activating mutations
occur in 2% of lung cancers. We assessed the activity of ado-trastuzumab emtansine, a HER2-…

Purpose: KRAS mutations occur in approximately 25% of patients with non–small cell lung
cancer (NSCLC). Despite the uniform presence of KRAS mutations, patients with KRAS-…

Importance Tumor genetic sequencing identifies potentially targetable genetic alterations
with therapeutic implications. Analysis has concentrated on detecting tumor-specific variants, …

Background Cancer is a heterogeneous disease with many genetic variations. Lines of
evidence have shown copy number variations (CNVs) of certain genes are involved in …

Purpose: To identify molecular factors that determine duration of response to EGFR tyrosine
kinase inhibitors and to identify novel mechanisms of drug resistance, we molecularly …

Background: Bisphenol A (BPA) is a base chemical used extensively in many consumer
products. BPA and its analogues are present in environmental and human samples. Many …