Cancer stem cells (CSCs) are hypothesized to be the main culprit of lung cancer progression.
Clinicopathological significance of stem cell markers CD133 and ALDH1 in a large group …

Background In 2012, Iranian's economy collapsed under strain from sanctions instituted to
stop Iran from violating the International Nuclear Non-Proliferation Treaty. Sanctions have …

Background Ischemia-reperfusion injury (IRI) of the liver is a well-known cause of morbidity
and mortality after liver transplantation. Effective treatment strategies aimed at decreasing …

Aim: The aim of this study was to investigate the hypothesis that the opioid system is
involved in the development of hepatic fibrosis. Methods: The effect of naltrexone (an opioid …

Background: The aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is one of the
promising markers for identifying cancer stem cells in many cancer types, along with other …

Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases
from the tumor core to the tumor periphery in a gradient pattern in a variety of solid tumors …

Ovarian cancer remains the most common cause of gynecologic cancer-related death
among women in developed countries. Nevertheless, subgroups of ovarian cancer patients …

Codelivery of chemo-sensitizers with chemotherapeutics using combo nanomedicine is a
promising platform for overcoming chemoresistance in breast cancer. However, tumor …

microRNAs are small single-stranded non-coding RNA molecules which modify gene expression
by silencing potential target genes. The aberrant expression of RhoA, a small GTPase …

BACKGROUND: According to the cancer stem cell theory, tumors originate from a subset of
cells known as cancer stem cells (CSCs) that are responsible for tumor initiation, resistance …