Background Cardiac muscle hypercontractility is a key pathophysiological abnormality in
hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (…

Background Left ventricular outflow tract (LVOT) obstruction is a major determinant of heart
failure symptoms in obstructive hypertrophic cardiomyopathy (oHCM). Aficamten, a next-in-…

CORRESPONDENCE index ([(1− global extracellular volume fraction)× LV mass]/body
surface index) decreased with mavacamten (− 14.1 [9.5] g/m2) versus no change in placebo (− …

We performed a systematic review of the current state of the literature regarding the natural
history and outcomes of bicuspid aortic valve (BAV). PubMed and the reference lists of the …

Background Transthyretin amyloid cardiomyopathy is characterized by the deposition of
misfolded monomeric transthyretin (TTR) in the heart. Acoramidis is a high-affinity TTR stabilizer …

Importance Whether vigorous intensity exercise is associated with an increase in risk of
ventricular arrhythmias in individuals with hypertrophic cardiomyopathy (HCM) is unknown. …

Background— Thoracic radiation results in radiation-associated heart disease (RAHD), often
requiring cardiothoracic surgery (CTS). We sought to measure long-term survival in RAHD …

Aims Advances in diagnostic imaging have increased the recognition of coexisting
transthyretin cardiac amyloidosis (ATTR‐CA) and severe aortic stenosis (AS), with a reported …

Sports-related sudden cardiac death (SrSCD) is a catastrophic event and a leading medical
cause of death in athletes (1). The incidence of SrSCD is debated with estimates ranging …

Introduction Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive, fatal and
under-recognized disease. This targeted literature review assessed the extent and …