Microglia are resident immune cells in the brain and spinal cord. These cells provide immune
surveillance and are mobilized in response to disparate diseases and injuries. Although …

SB Prusiner proposed that the infectious agent of scrapie, the prion, is PrP Sc , a modified
form of the normal host protein PrP c . Prn-p 0/0 mice devoid of PrP c showed normal …

LIMB muscles develop from cells that migrate from the somites 1,2 . The signal that induces
migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb …

Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that
are caused by prions and affect humans and many animal species. It is now widely accepted …

Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru
decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions …

Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

ACCUMULATION of the prion protein PrP Sc , a pathological and protease-resistant isoform
of the normal host protein PrP c , is a feature of prion disease such as scrapie 1,2 . It is still …

The differentiation of follicular dendritic cells (FDC) is essential to the remarkable
microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous …

We present an analytical treatment of a set of coupled kinetic equations that governs the self-assembly
of filamentous molecular structures. Application to the case of protein aggregation …

The role of the glucocorticoid receptor (GR) in glucocorticoid physiology and during development
was investigated by generation of GR-deficient mice by gene targeting. GR -/- mice die …