A new strategy for organocatalysis based on the biochemical blueprints of biosynthesis has
enabled a new laboratory approach to cascade catalysis. Imidazolidinone-based catalytic …

Within the realm of catalytic asymmetric hydrogenation, the focus continues to be on the use
of chiral metal complexes in conjunction with a hydrogen source. Recently, the widespread …

The discovery of new strategies that emulate nature s capacity to rapidly construct architectural
complexity continues to be a central focus for research and development in the chemical …

Millions of years of evolution have allowed Nature to develop ingenious synthetic strategies
and reaction pathways for the construction of architectural complexity. In contrast, the field of …

A PET tracer is desired to help guide the discovery and development of disease-modifying
therapeutics for neurodegenerative diseases characterized by neurofibrillary tangles (NFTs), …

Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the
pathologic hallmark of several neurodegenerative diseases including Alzheimer’s disease. …

The first enantioselective organocatalytic α-allylation of cyclic ketones has been accomplished
via singly occupied molecular orbital catalysis. Geometrically constrained radical cations, …

Background: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density
lipoprotein receptor interaction with injectable monoclonal antibodies or small interfering …

Dirhodium tetracarboxylates are readily immobilized on agitation in the presence of highly
cross-linked polystyrene resins with a pyridine attachment. A systematic study demonstrates …

Heterogenization of dirhodium tetrakis((S)-N-dodecylbenzenesulfonyl)prolinate) (Rh 2 (S-DOSP)
4 ) can be readily achieved on a pyridine functionalized highly cross-linked polystyrene …