Detection of epidermal growth factor receptor (EGFR) overexpression in many carcinomas
provides important diagnostic information, which can influence patient management. The use …

The objective of this study was to compare the results of three nociceptive tests, tail‐flick, hot‐plate
and electrical stimulation vocalisation, reflecting the responses from different sites in …

The local anesthetic lidocaine suppresses different pain conditions when administered
systemically. Part of the antinociceptive effect appears to be mediated via receptor mechanisms. …

New ventilated caging systems for laboratory animals were compared with conventional
caging regarding allergen distribution, ergonomic suitability, cage environment and animal …

Active efflux transporters in the blood–brain barrier lower the brain concentrations of many
drug molecules and endogenous substances and thus affect their central action. The …

Objective: The aim of the present study was to investigate the intra-articular duration of
Durolane™ in a rabbit model to allow comparison between Durolane™ residence time and data …

Both systemically and intrathecally administered cholinergic agonists produce antinociception
while cholinergic antagonists decrease pain threshold. The mechanism and the site of …

The serotonin transporter radioligand [ 11 C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile,
or [ 11 C]DASB, was examined in order to assess its potential for …

Cholinergic agonists produce spinal antinociception via mechanisms involving an increased
release of intraspinal acetylcholine. The cholinergic receptor system interacts with several …

Dutta and coworkers suggest in a recent letter (1) that the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) nucleoprotein (N) might be a good vaccine target. They argue …