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26429962,28049295,23525982,23096164,32022567,31706737,22736376,26385534,29314858,26402157,27987070,19409037,12960194,10809207,27788375,20554744,30429889,19617342,17631548,35926098,26848176,27813061,22918766,10716315,17785729,11585869,29957952,22214307,21711096,33479914,30589553,14960657,35575711,15235070,26469142,24883121,24472064,25785845,22643311,25919639,19034582,33342808,26596724,33169241,21958849,21220136,28705917,19924993,28423546,18703606,11390564,15838425,19837760,21498540,18678349,30663095,27813707,23551110,17671747,16203806,10821648,29502411,10363986,23166961,23963362,26447839,24824962,23901833,26917708,27196891,12640557,21796623,20150272,23528382,15691661,26081917,33052220,19423002,16269605,20870149,30390575,31242384,17127172,22907419,23618841,28821931,17307125,18942092,17363599,15289297,22137850,28232604,8319209,26341366,26514177,14633715,26974228,26625938,36377696,14503946,32661830,22434639,31624380,11751413,23564760,29571067,32062317,2795690,34182918,21055626,21849406,30974402,12384535,12515879,22819196,29777377,32196365,27524505,32255676,30912951,22980441,21153409,31588245,12902420,17470737,25226447,12543788,31149033,20682654,34383182,20554729,26659353,31931305,23035309,21890879,31077356,17704253,23615858,22159179,21572364,17998090,27166974,25893775,24859811,16741313,15791435,36972439,22973578,18632822,28104744,11340564,31273351,21348052,16193312,23136679,8306291,29684274,21348051,23035311,18227029,25349977,28514062,18632642,19217523,21348055,21348053,26514174,8735485,17699871,23551111,19423003,12843231,24337604,24267052,18712381,12031878,27831759,20716957,26545016,20641910,27119227,17545543,23294030,12616957,21984380,27258216,9443731,31804840,21247151,21843781,21282735,30633529,31309259,9804044,34879870,30733320,23922757,15347722,30655327,26673416,22879947,24732154,15994969,36357179,21767082,16710024,22739362,31321650,22280117,29232309,33494011,28116540,16082184,14503955,27609789,16203816,32042334,16720239,17096340,33078260,25999431,31754913,17363549,21348054,35759660,30253737,24643779,14506192,18593929,29959213,29921305,24227890,20036116,34433438,20641447,20641906,15342405,15774166,25391547,12902421,31483993,18245551,23081995,29777007,21072513,18158949,26718028,22824293,25766325,15653647,24029656,19430786,18298335,26066655,27399687,30825614,24944121,22896860,16720237,15131055,7957350,20499311,28254866,9426693,27270318,11711308,18265976,28751451,17210705,20641264,32657634,29439013,26748017,20641849,30765854,31534505,27497632,22881720,27363028,18454685,32289441,8340945,23708872,17651048,24982330,23160926,20641524,26068969,30081724,29109513,28916621,9627341,32330574,23674207,15153445,32245896,29865791,16033825,34757737,34145369,20127951,22229017,26062654,22348532,2253238,30736768,31087550,17210714,36516432,22003817,29715105,10346884,23236020,19846943,19647172,9575242,20641379,17828616,24927340,16253810,19525458,25164771,24578241,29502416,20641430,22787684,22787683,22787682,36127494,27419360,20610170,32822783,23089711,30154145,28347861,21816968,33348564,27748184,33042258,16269603,11312688,17651039,26573511,11483692,17579472,20525277,26181203,24100768,7738660,16203807,20642017,10740655,27813128,12009958,9060958,17982120,22510481,15453954,22222630,32770372,17021818,20641705,27076760,29077574,32889587,26912441,19324561,31965330,31337646,19720293,24643780,35046060,21982897,29574636,32787284,30612308,15068616,18722269,29674421,23166962,34406146,32106568,23722548,34198999,26999580,19681874,25919487,24665085,30821463,19647173,16140951,27908170,36129807,29606874,28067257,25459109,16536481,31862799,34626281,23101054,28938164,21204763,20358420,25637565,19155297,28082435,31891487,17979567,34711617,29413459,26177233,28864631,29129050,30196384,19922304,22191655,32550914,27264196,27688477,23358664,16755333,25068508,22993872,35910795,24979648,20707718,29328489,26912425,31251311,17268025,26686087,27888699,28409338,31033025,35428777,30682091,20641634,30254080,8485492,26498681,34194285,12892230,20641695,28062708,33371333,8509857,12005541,33268703,28496321,14734682,34517630,26332194,17105236,28732021,25577038,37064291,33574346,18589302,29502423,11416113,29653973,29733658,26705852,27776176,26525951,19164241,23873478,35325547,24030631,17045168,10615242,32285356,27430985,21177408,31513391,18999934,21858527,33547212,32089070,22336201,33646782,35631396,28450563,31827645,16423478,24292501,29658563,26077887,26763588,28810153,26159589,29502008,28915583,34839209,17651043,31547586,27225450,29556616,22214432,28861553,32711088,29895866,17947470,27283923,30425482,7828373,32170344,26722378,35878454,15846117,31183315,10363798,32737245,25717229,25389697,23516616,11745491,36499504,27740752,10786684,29952132,23256748,24730235,33246602,33679691,33859761,11341788,33916671,36542157,28301261,26116117,20956481,19910417,26892017,27035553,29028502,37115407,11255078,31519804,14605881,16203818,24104523,36352185,33606344,34997132,14506184,26949707,15765233,15519153,30052070,23556153,33772068,7889541,31993928,25906708,24516620,26625257,20641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02,36781849,36508552,33092037,31900443,35778612,34867325,34260732,30444328,23210841,22302484,34151070,36797602,28616585,8279780,28777832,11091609,26405603,34959652,26085854,36432639,29037986,32483396,34775465,36825111,35406609,35901977,32486340,36519541,31681603,33144340,26230702,35745775,14661643,34611335,24377038,22330249,36268127,8295759,24693197,32533051,23170279,36347949,3488977,19870302,30914052,9982863[uid]

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Dual-Receptor-Targeted Radioimmunotherapy of Human Breast Cancer Xenografts in Athymic Mice Coexpressing HER2 and EGFR Using 177Lu- or 111In-Labeled Bispecific Radioimmunoconjugates.

Razumienko EJ, Chen JC, Cai Z, Chan C, Reilly RM. Razumienko EJ, et al. J Nucl Med. 2016 Mar;57(3):444-52. doi: 10.2967/jnumed.115.162339. Epub 2015 Oct 1. J Nucl Med. 2016. PMID: 26429962 Free article.

⁶⁴Cu-Labeled Trastuzumab Fab-PEG₂₄-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents.

Kwon LY, Scollard DA, Reilly RM. Kwon LY, et al. Mol Pharm. 2017 Feb 6;14(2):492-501. doi: 10.1021/acs.molpharmaceut.6b00963. Epub 2017 Jan 18. Mol Pharm. 2017. PMID: 28049295

MicroSPECT/CT imaging of co-expressed HER2 and EGFR on subcutaneous human tumor xenografts in athymic mice using ¹¹¹In-labeled bispecific radioimmunoconjugates.

Razumienko E, Dryden L, Scollard D, Reilly RM. Razumienko E, et al. Breast Cancer Res Treat. 2013 Apr;138(3):709-18. doi: 10.1007/s10549-013-2490-5. Epub 2013 Mar 24. Breast Cancer Res Treat. 2013. PMID: 23525982

Small-animal SPECT/CT of HER2 and HER3 expression in tumor xenografts in athymic mice using trastuzumab Fab-heregulin bispecific radioimmunoconjugates.

Razumienko EJ, Scollard DA, Reilly RM. Razumienko EJ, et al. J Nucl Med. 2012 Dec;53(12):1943-50. doi: 10.2967/jnumed.112.106906. Epub 2012 Oct 24. J Nucl Med. 2012. PMID: 23096164 Free article.

Dual-Receptor-Targeted (DRT) Radiation Nanomedicine Labeled with ¹⁷⁷Lu Is More Potent for Killing Human Breast Cancer Cells That Coexpress HER2 and EGFR Than Single-Receptor-Targeted (SRT) Radiation Nanomedicines.

Yook S, Cai Z, Jeong JJ, Lu Y, Winnik MA, Pignol JP, Reilly RM. Yook S, et al. Mol Pharm. 2020 Apr 6;17(4):1226-1236. doi: 10.1021/acs.molpharmaceut.9b01259. Epub 2020 Mar 3. Mol Pharm. 2020. PMID: 32022567

Effectiveness and normal tissue toxicity of Auger electron (AE) radioimmunotherapy (RIT) with [¹¹¹In]In-Bn-DTPA-nimotuzumab in mice with triple-negative or trastuzumab-resistant human breast cancer xenografts that overexpress EGFR.

Chan C, Fonge H, Lam K, Reilly RM. Chan C, et al. Nucl Med Biol. 2020 Jan-Feb;80-81:37-44. doi: 10.1016/j.nucmedbio.2019.10.001. Epub 2019 Oct 22. Nucl Med Biol. 2020. PMID: 31706737

¹¹¹In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic agent for EGFR-positive and trastuzumab (Herceptin)-resistant breast cancer.

Fasih A, Fonge H, Cai Z, Leyton JV, Tikhomirov I, Done SJ, Reilly RM. Fasih A, et al. Breast Cancer Res Treat. 2012 Aug;135(1):189-200. doi: 10.1007/s10549-012-2137-y. Epub 2012 Jun 27. Breast Cancer Res Treat. 2012. PMID: 22736376

A comparison of non-biologically active truncated EGF (EGFt) and full-length hEGF for delivery of Auger electron-emitting 111In to EGFR-positive breast cancer cells and tumor xenografts in athymic mice.

Panosa C, Fonge H, Ferrer-Batallé M, Menéndez JA, Massaguer A, De Llorens R, Reilly RM. Panosa C, et al. Nucl Med Biol. 2015 Dec;42(12):931-8. doi: 10.1016/j.nucmedbio.2015.08.003. Epub 2015 Aug 19. Nucl Med Biol. 2015. PMID: 26385534

Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to ¹¹¹In and ¹⁷⁷Lu-An EGFR-Targeted Theranostic for Pancreatic Cancer.

Aghevlian S, Lu Y, Winnik MA, Hedley DW, Reilly RM. Aghevlian S, et al. Mol Pharm. 2018 Mar 5;15(3):1150-1159. doi: 10.1021/acs.molpharmaceut.7b01000. Epub 2018 Jan 30. Mol Pharm. 2018. PMID: 29314858

Radiation Nanomedicine for EGFR-Positive Breast Cancer: Panitumumab-Modified Gold Nanoparticles Complexed to the β-Particle-Emitter, (177)Lu.

Yook S, Cai Z, Lu Y, Winnik MA, Pignol JP, Reilly RM. Yook S, et al. Mol Pharm. 2015 Nov 2;12(11):3963-72. doi: 10.1021/acs.molpharmaceut.5b00425. Epub 2015 Oct 7. Mol Pharm. 2015. PMID: 26402157

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