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25476538,26205538,24325578,17307127,24790219,27864853,18651641,19173265,20936685,10956195,16606355,20340171,26655303,9435894,26422464,17001660,12515884,15028242,8531103,17375087,15306199,22034017,12930145,16952157,7562534,23238770,16416444,16786538,16715499,12679408,35732005,7790957,18158938,19755662,15878504,22915159,20093397,17056032,8278895,10411608,10842352,27209485,11494399,17497628,27236283,14660713,21878947,22577236,20680481,9375667,19957364,20860881,31740395,11056366,9536001,21780185,15352133,15937307,20117160,19598174,24480780,16736043,23623679,16014571,21990574,14530487,15943487,32011892,15193608,19372485,16824659,8996185,25935386,15689168,19957365,27789720,16134944,21994970,12570798,20956470,25556097,24910074,23618707,25840364,23504964,22213714,10473190,8632703,22460766,31571826,25002365,15024551,36525123,25199843,26386360,28421623,22642365,22591915,27589704,23562464,18551280,9600324,30683765,33844498,26216275,29730825,28254508,12831994,31473354,24831693,22899645,18785726,11929698,25963911,22659483,21308799,23297076,12023552,10691686,35849844,21218455,22535514,22213512,11578899,26388148,19910432,10435376,21174090,25071097,23664955,19301416,9257944,24602412,19562698,29106979,12880838,23041777,18072730,25637276,20641295,11823129,10638823,32737247,20641608,21479533,27035329,27379794,22464847,32718750,26090686,18482682,12086487,22173841,7990123,22927303,32818617,20175227,24799619,9473144,27374277,20583987,1399687,27230925,24480269,24285319,26405172,24793011,28011253,25296765,30844536,11210099,16469510,8788068,25583220,10628551,23540907,9132991,25338762,24874713,27341789,25716779,28917111,29948643,8761017,30811975,10096507,16918344,30733317,23141552,10956209,26232153,23723346,23239525,35289620,21204317,28857231,21843786,11814775,12628671,12847556,19875049,3873656,10082890,14522006,19217026,24857865,18274730,20641325,31257877,25601336,24898025,29641175,27801563,18410082,26608176,33851345,22933820,22968323,29334326,30662550,20038106,20641879,27856625,29509680,16333673,25024426,33450620,25439096,22699528,20702763,1300511,7953659,12031882,23238524,30659274,27091456,24960209,32298690,8982716,24480268,8535343,30588600,10363800,20641389,11087581,7674830,26872437,19203271,1827499,1833546,20804495,12361386,20146482,29445200,14684327,14697776,24854795,23333701,29518538,20336622,11297811,27343365,27199360,30981605,26886507,16854086,31728839,20641291,31982883,20097293,27123902,22226022,25814099,29400443,30206613,21718948,7582561,23149560,21680697,22492734,12161137,23810488,10473192,23994301,33548637,27199364,24525206,22851633,7566703,12060799,20641398,21072511,29747036,23224422,26155312,26843180,22822714,21752340,12166939,32342685,10691700,22077717,2143753,28409931,35182773,7830274,21945484,22315216,24183588,3346882,23038748,21620533,24732791,36521341,21132811,10525759,22571907,25248756,1652023,25247893,25734236,28289968,10771033,28528265,30698943,27128179,23207573,21613502,24865402,24470629,31838339,24337599,11000009,27591013,27132867,30630942,26707848,11844688,25082853,35420022,12369994,21584868,28716664,10794704,32828429,27821345,20641474,23018094,24714035,19181263,31659519,8674731,25539635,3258305,23141549,36747738,21888437,18220966,35710735,21930214,24935992,29191857,19372471,35216115,25263130,19904285,33579806,28315263,20680268,23165140,22853801,17583908,26979158,2944753,25451213,28870802,29537837,2143387,9873601,28670707,36656363,28856700,22154685,19211895,8485486,18534857,27150034,26461182,11711286,10757512,23218776,19720528,26360510,25400260,21680683,34699207,37017827,31919878,8246241,11597417,25248453,21567969,34675381,2391685,28338530,25977878,30360553,9171869,36613875,26108234,28300398,20447563,30516998,36571976,1394695,18849360,32847148,22871578,30409657,27280499,34797051,14499480,24862069,33318558,21609773,31924728,12213467,22323774,22968817,21958848,23999545,35642985,25610643,10386940,8824240,15983793,7633333,22290740,12470717,17096093,31678782,24848155,10732964,18355689,33918451,31606832,28379199,26905976,10722154,20558302,21219928,23223380,20182818,34536549,29644713,35771668,29643252,19193901,15644875,32787100,28248104,17706924,22445742,23334237,28272861,22315215,27896627,11711295,28489379,19425052,30883109,29031113,11112086,30973705,20641338,30772268,30414212,9234291,30665144,21538900,28495386,26442600,18176804,30131592,9316078,32282200,31648134,14617818,19956086,30124143,20946109,29106549,20657759,21737287,26384292,7727157,34855308,10996008,11212112,34651220,24676756,35150243,20182714,27073203,29451744,24376058,17909794,27983845,3255742,22167235,1321101,27821347,20808319,30151086,22336372,1330979,26048782,24077804,7861413,27029585,16285909,8504293,34523611,22231017,22162756,24160350,18674906,28968497,29244904,31940507,1526814,36754138,22778874,23514539,29683325,19788498,30375667,35802702,11512277,30849613,7758672,28648984,35468416,36215695,11594441,32981322,23133799,28769801,31674045,23314019,30015093,29053271,33548201,30394757,31657559,34757711,10512490,35397430,29215308,24555564,32246980,3611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Synthesis and evaluation in rats of the dopamine D2/3 receptor agonist 18F-AMC20 as a potential radioligand for PET.

Shalgunov V, van Wieringen JP, Janssen HM, Fransen PM, Dierckx RA, Michel MC, Booij J, Elsinga PH. Shalgunov V, et al. J Nucl Med. 2015 Jan;56(1):133-9. doi: 10.2967/jnumed.114.145466. Epub 2014 Dec 4. J Nucl Med. 2015. PMID: 25476538 Free article.

Synthesis and evaluation in rats of homologous series of [(18)F]-labeled dopamine D 2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers.

Shalgunov V, van Wieringen JP, Janssen HM, Fransen PM, Dierckx RA, Michel MC, Booij J, Elsinga PH. Shalgunov V, et al. EJNMMI Res. 2015 Dec;5(1):119. doi: 10.1186/s13550-015-0119-x. Epub 2015 Jul 25. EJNMMI Res. 2015. PMID: 26205538 Free PMC article.

Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D₂/₃ receptors in their high-affinity state.

van Wieringen JP, Shalgunov V, Janssen HM, Fransen PM, Janssen AG, Michel MC, Booij J, Elsinga PH. van Wieringen JP, et al. J Med Chem. 2014 Jan 23;57(2):391-410. doi: 10.1021/jm401384w. Epub 2014 Jan 2. J Med Chem. 2014. PMID: 24325578

Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [(18)F]F-PHNO.

Vasdev N, Seeman P, Garcia A, Stableford WT, Nobrega JN, Houle S, Wilson AA. Vasdev N, et al. Nucl Med Biol. 2007 Feb;34(2):195-203. doi: 10.1016/j.nucmedbio.2006.11.001. Epub 2007 Jan 17. Nucl Med Biol. 2007. PMID: 17307127

(18)F-MCL-524, an (18)F-Labeled Dopamine D2 and D3 Receptor Agonist Sensitive to Dopamine: A Preliminary PET Study.

Finnema SJ, Stepanov V, Nakao R, Sromek AW, Zhang T, Neumeyer JL, George SR, Seeman P, Stabin MG, Jonsson C, Farde L, Halldin C. Finnema SJ, et al. J Nucl Med. 2014 Jul;55(7):1164-70. doi: 10.2967/jnumed.113.133876. Epub 2014 May 1. J Nucl Med. 2014. PMID: 24790219 Free PMC article.

PET radiotracer development for imaging high-affinity state of dopamine D2 and D3 receptors: Binding studies of fluorine-18 labeled aminotetralins in rodents.

Mukherjee J, Majji D, Kaur J, Constantinescu CC, Narayanan TK, Shi B, Nour MT, Pan ML. Mukherjee J, et al. Synapse. 2017 Mar;71(3):10.1002/syn.21950. doi: 10.1002/syn.21950. Epub 2016 Nov 30. Synapse. 2017. PMID: 27864853 Free PMC article.

Occupancy of dopamine D2/3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [11C]MNPA.

Seneca N, Zoghbi SS, Skinbjerg M, Liow JS, Hong J, Sibley DR, Pike VW, Halldin C, Innis RB. Seneca N, et al. Synapse. 2008 Oct;62(10):756-63. doi: 10.1002/syn.20549. Synapse. 2008. PMID: 18651641 Free PMC article.

Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA.

Finnema SJ, Halldin C, Bang-Andersen B, Gulyás B, Bundgaard C, Wikström HV, Farde L. Finnema SJ, et al. Synapse. 2009 May;63(5):378-89. doi: 10.1002/syn.20615. Synapse. 2009. PMID: 19173265

In vitro and in vivo comparison of [³H](+)-PHNO and [³H]raclopride binding to rat striatum and lobes 9 and 10 of the cerebellum: a method to distinguish dopamine D₃ from D₂ receptor sites.

Kiss B, Horti F, Bobok A. Kiss B, et al. Synapse. 2011 Jun;65(6):467-78. doi: 10.1002/syn.20867. Epub 2010 Nov 9. Synapse. 2011. PMID: 20936685

Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).

van Vliet LA, Rodenhuis N, Dijkstra D, Wikström H, Pugsley TA, Serpa KA, Meltzer LT, Heffner TG, Wise LD, Lajiness ME, Huff RM, Svensson K, Sundell S, Lundmark M. van Vliet LA, et al. J Med Chem. 2000 Jul 27;43(15):2871-82. doi: 10.1021/jm0000113. J Med Chem. 2000. PMID: 10956195

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