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16818951,10537296,11306477,15592447,8521403,10429512,16818948,14513292,15585483,12163634,19223410,18344433,11197989,12719705,19217533,11751394,8797571,10880025,15161034,11263189,16644759,9766661,16086864,11286034,26656427,9614564,11440032,10766347,16779868,11749772,9772430,8729908,10774880,10467366,15043787,10632364,8988840,11857036,21982570,15185012,12475412,15250149,17509714,10800091,12509912,11205314,15010834,20083410,10945625,7585511,19896764,12457278,11326946,11916247,11356068,9865731,11477459,15854489,9037277,12920859,11393284,16802401,10933914,9973216,12964030,10933975,10866313,10628368,12885362,11319623,9708520,10490775,12386830,11318113,14502232,18309353,11280727,10195885,11997547,10891564,17294333,8940635,16762858,11498775,10678364,15632039,10950389,16278396,17409415,15359292,15026990,18077523,18413388,15905861,11045430,10537302,15534063,17713568,11916241,10985951,10830728,18432182,15248913,10435092,10678355,17406570,15982576,10078964,9889024,11306482,10811473,16039533,10920915,18811956,18504196,16465423,9639739,20819721,10770629,18583225,11045429,17406603,9721854,18367126,9930343,15312323,8626129,18560942,16511352,11426331,15107812,9772431,24316433,14693048,11129288,17407070,15499377,22914496,11948376,25545853,11687892,11696640,16217556,12497062,12869633,11702112,9853135,15759279,10749133,19604626,15646826,19024294,17193264,18834973,20641413,15059319,11433353,19506865,10476214,12783658,16954695,18188770,11930726,9425438,12796736,10880027,9012451,9950583,16685452,8283035,16843840,12101433,12666188,11263528,11313808,11021592,9829598,12212546,16224495,8047987,16480582,11110418,10880026,19345377,14584954,11314087,17016620,11716505,12133366,16595506,10684701,17364733,12536204,9699645,16913728,10341876,11916238,9216837,12579310,19910419,11776567,22781033,15067374,24054501,8646554,16041591,15942661,11812079,16620557,15145177,10435106,26429860,18096314,10678353,11082325,8788175,17611584,17960926,12903520,23533367,24926696,11859423,8917361,20346877,10226527,14660047,22498724,11263529,11337525,16546268,10933050,8687114,18929831,18006778,18096302,9012446,15729367,9228920,20460047,8022417,17206416,16615496,10450690,18390175,15219281,12679798,9472560,9225789,14602869,10810381,11859419,17013529,12872144,12833126,16643751,14695756,12525837,8395331,9349427,10226526,15592511,17695518,17274368,12224023,15699008,16079887,12569563,11877036,21924768,12016970,12452035,12536197,16171563,9425449,11039021,12170381,12664136,12761956,11263531,12189525,10678363,10678358,17950092,15296672,15761475,9824047,10463570,16269608,14648229,14696255,14681722,18157580,22130503,9917093,17487205,10455417,8971399,23536224,20137546,10395379,15243631,22514809,11526536,17611695,11896443,14681723,11127592,17083794,21906771,12111114,10435100,12390841,32691392,12601392,12014627,15163659,16793160,10770632,9135738,11773974,10720079,11299758,9731497,12402300,10476212,11829460,16307003,14607709,9815692,15600178,11571537,12639307,14579096,9135011,14595377,15916863,9536272,16004805,11866443,16818950,11853412,1338622,11072029,23018623,10811474,14661177,15727862,10341871,12760771,11483684,15474666,10961956,16724095,21958846,23009582,12974091,16008895,11973634,16340720,15378285,7671107,11836603,11482986,15118758,15375516,9813672,15342393,9537229,15483667,7584128,15280909,12637938,8988843,9415310,11498761,15196433,16253805,11874632,15170736,12173067,15826723,15472716,12417082,21718951,11718086,8664377,12615710,16052225,11482988,16570015,10822306,12920846,12208748,11313793,29660022,27275821,11070906,16095973,11118367,11845986,2733785,15552038,10601281,9610071,12573058,15996701,11860708,16322528,10798672,9202536,11571568,9673364,14530205,8930659,14671673,9570299,14681725,24312266,29584688,15181182,12905896,22402625,12545814,15775995,15816546,12424609,9025757,16367913,15614446,8752480,8700554,15598073,15504552,15818381,17512546,20641657,11606369,20925460,16829761,15854348,9596975,18984872,8673619,20641753,9358032,11356082,16110312,8853551,17007882,11930269,20599444,15756291,21718941,15014901,12743320,19927639,15347725,11960288,19181266,16330572,9415318,14689242,16810197,12192082,15891776,3002245,9425442,11888920,20641334,11238837,19259663,11916249,12016973,11319910,11093770,15905857,29306975,11245422,24669276,28255357,10880028,15619289,7603465,12526317,22147660,10716999,12489030,11212841,15803141,15145121,8727370,24639460,14727689,8825863,16243818,11916243,10758606,12209705,28727740,17707813,9813658,9029509,10933953,9405242,23174140,11676546,21904395,30958558,10476232,11228530,8668538,16040278,11396148,8894676,7910373,25596375,12457279,10894261,19741734,12894520,12888917,9457219,19931566,32958548,11160865,24140055,11948367,16529724,10965923,21565234,33801024,12869307,11002255,9853525,9759929,7565681,15853805,9024200,18077534,20128998,12652311,12538436,11708886,16390269,15543525,11912175,11212842,18972602,15464975,16258092,11704818,12538910,15721383,15093809,10455405,7882139,11431140,16128746,15068619,12920847,15891772,12187266,21331450,29197132,15988610,16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Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.

Wang HE, Yu HM, Liu RS, Lin M, Gelovani JG, Hwang JJ, Wei HJ, Deng WP. Wang HE, et al. J Nucl Med. 2006 Jul;47(7):1161-71. J Nucl Med. 2006. PMID: 16818951 Free article.

Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.

Tjuvajev JG, Chen SH, Joshi A, Joshi R, Guo ZS, Balatoni J, Ballon D, Koutcher J, Finn R, Woo SL, Blasberg RG. Tjuvajev JG, et al. Cancer Res. 1999 Oct 15;59(20):5186-93. Cancer Res. 1999. PMID: 10537296

Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.

Jacobs A, Tjuvajev JG, Dubrovin M, Akhurst T, Balatoni J, Beattie B, Joshi R, Finn R, Larson SM, Herrlinger U, Pechan PA, Chiocca EA, Breakefield XO, Blasberg RG. Jacobs A, et al. Cancer Res. 2001 Apr 1;61(7):2983-95. Cancer Res. 2001. PMID: 11306477

Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.

Yaghoubi SS, Barrio JR, Namavari M, Satyamurthy N, Phelps ME, Herschman HR, Gambhir SS. Yaghoubi SS, et al. Cancer Gene Ther. 2005 Mar;12(3):329-39. doi: 10.1038/sj.cgt.7700795. Cancer Gene Ther. 2005. PMID: 15592447

Imaging the expression of transfected genes in vivo.

Tjuvajev JG, Stockhammer G, Desai R, Uehara H, Watanabe K, Gansbacher B, Blasberg RG. Tjuvajev JG, et al. Cancer Res. 1995 Dec 15;55(24):6126-32. Cancer Res. 1995. PMID: 8521403

Herpes simplex virus thymidine kinase as a marker/reporter gene for PET imaging of gene therapy.

Blasberg RG, Tjuvajev JG. Blasberg RG, et al. Q J Nucl Med. 1999 Jun;43(2):163-9. Q J Nucl Med. 1999. PMID: 10429512 Review.

Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET.

Tseng JC, Zanzonico PB, Levin B, Finn R, Larson SM, Meruelo D. Tseng JC, et al. J Nucl Med. 2006 Jul;47(7):1136-43. J Nucl Med. 2006. PMID: 16818948 Free article.

Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir.

Deng WP, Yang WK, Lai WF, Liu RS, Hwang JJ, Yang DM, Fu YK, Wang HE. Deng WP, et al. Eur J Nucl Med Mol Imaging. 2004 Jan;31(1):99-109. doi: 10.1007/s00259-003-1269-z. Epub 2003 Sep 25. Eur J Nucl Med Mol Imaging. 2004. PMID: 14513292

Synthesis and evaluation of 2'-deoxy-2'-18F-fluoro-5-fluoro-1-beta-D-arabinofuranosyluracil as a potential PET imaging agent for suicide gene expression.

Alauddin MM, Shahinian A, Park R, Tohme M, Fissekis JD, Conti PS. Alauddin MM, et al. J Nucl Med. 2004 Dec;45(12):2063-9. J Nucl Med. 2004. PMID: 15585483 Free article.

Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression.

Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, Finn R, Bornmann W, Thaler H, Conti PS, Blasberg RG. Tjuvajev JG, et al. J Nucl Med. 2002 Aug;43(8):1072-83. J Nucl Med. 2002. PMID: 12163634 Free article.

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