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1

Preclinical pharmacokinetic, biodistribution, toxicology, and dosimetry studies of 111In-DTPA-human epidermal growth factor: an auger electron-emitting radiotherapeutic agent for epidermal growth factor receptor-positive breast cancer.

Reilly RM, Chen P, Wang J, Scollard D, Cameron R, Vallis KA. Reilly RM, et al. J Nucl Med. 2006 Jun;47(6):1023-31. J Nucl Med. 2006. PMID: 16741313 Free article.

2

Antitumor effects and normal tissue toxicity of 111In-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive human breast cancer xenografts.

Chen P, Cameron R, Wang J, Vallis KA, Reilly RM. Chen P, et al. J Nucl Med. 2003 Sep;44(9):1469-78. J Nucl Med. 2003. PMID: 12960194 Free article.

3

111In-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR.

Reilly RM, Kiarash R, Cameron RG, Porlier N, Sandhu J, Hill RP, Vallis K, Hendler A, Gariépy J. Reilly RM, et al. J Nucl Med. 2000 Mar;41(3):429-38. J Nucl Med. 2000. PMID: 10716315 Free article.

4

A comparison of EGF and MAb 528 labeled with 111In for imaging human breast cancer.

Reilly RM, Kiarash R, Sandhu J, Lee YW, Cameron RG, Hendler A, Vallis K, Gariépy J. Reilly RM, et al. J Nucl Med. 2000 May;41(5):903-11. J Nucl Med. 2000. PMID: 10809207 Free article.

5

Epidermal growth factor receptor inhibition modulates the nuclear localization and cytotoxicity of the Auger electron emitting radiopharmaceutical 111In-DTPA human epidermal growth factor.

Bailey KE, Costantini DL, Cai Z, Scollard DA, Chen Z, Reilly RM, Vallis KA. Bailey KE, et al. J Nucl Med. 2007 Sep;48(9):1562-70. doi: 10.2967/jnumed.107.044073. Epub 2007 Aug 17. J Nucl Med. 2007. PMID: 17704253 Free article.

6

Preclinical pharmacokinetics, biodistribution, radiation dosimetry and acute toxicity studies required for regulatory approval of a Clinical Trial Application for a Phase I/II clinical trial of (111)In-BzDTPA-pertuzumab.

Lam K, Chan C, Done SJ, Levine MN, Reilly RM. Lam K, et al. Nucl Med Biol. 2015 Feb;42(2):78-84. doi: 10.1016/j.nucmedbio.2014.09.011. Epub 2014 Oct 14. Nucl Med Biol. 2015. PMID: 25459109

7

Phase I trial to evaluate the tumor and normal tissue uptake, radiation dosimetry and safety of (111)In-DTPA-human epidermal growth factor in patients with metastatic EGFR-positive breast cancer.

Vallis KA, Reilly RM, Scollard D, Merante P, Brade A, Velauthapillai S, Caldwell C, Chan I, Freeman M, Lockwood G, Miller NA, Cornelissen B, Petronis J, Sabate K. Vallis KA, et al. Am J Nucl Med Mol Imaging. 2014 Mar 20;4(2):181-92. eCollection 2014. Am J Nucl Med Mol Imaging. 2014. PMID: 24753984 Free PMC article.

8

Effect of the EGFR density of breast cancer cells on nuclear importation, in vitro cytotoxicity, and tumor and normal-tissue uptake of [111In]DTPA-hEGF.

Hu M, Scollard D, Chan C, Chen P, Vallis K, Reilly RM. Hu M, et al. Nucl Med Biol. 2007 Nov;34(8):887-96. doi: 10.1016/j.nucmedbio.2007.06.010. Epub 2007 Sep 4. Nucl Med Biol. 2007. PMID: 17998090

9

Multifunctional block copolymer micelles for the delivery of 111In to EGFR-positive breast cancer cells for targeted Auger electron radiotherapy.

Fonge H, Lee H, Reilly RM, Allen C. Fonge H, et al. Mol Pharm. 2010 Feb 1;7(1):177-86. doi: 10.1021/mp900201v. Mol Pharm. 2010. PMID: 19924993

10

A comparison of non-biologically active truncated EGF (EGFt) and full-length hEGF for delivery of Auger electron-emitting 111In to EGFR-positive breast cancer cells and tumor xenografts in athymic mice.

Panosa C, Fonge H, Ferrer-Batallé M, Menéndez JA, Massaguer A, De Llorens R, Reilly RM. Panosa C, et al. Nucl Med Biol. 2015 Dec;42(12):931-8. doi: 10.1016/j.nucmedbio.2015.08.003. Epub 2015 Aug 19. Nucl Med Biol. 2015. PMID: 26385534

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