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16391197,15534063,15471848,18984872,19223410,15347725,18413388,17406570,11896439,12105155,12187266,32691392,14579096,15592447,12538436,15007006,17786312,20540537,12457279,19372484,18157580,12040458,14724687,15543536,19296102,16269608,11526454,20223118,15632039,15988610,12640659,21161690,17704249,11696640,17409415,11306477,16041591,17297551,15073262,9829598,10716999,16204722,17150159,12960972,25545853,17505007,11483684,12833136,26016906,25031704,20641191,15302807,12692861,17492285,20522982,11916485,12489031,15585483,15242524,11997547,21982570,20032804,22796395,15746944,20641753,20801174,16595506,16340720,11197989,19259663,31829615,21531290,19641532,16278396,22981986,19819065,17532884,15144574,21411139,8793549,16894187,17574975,29858789,16544976,15809490,10537296,28255357,25294311,12095306,14963160,14645563,11745423,17942800,16391195,18030991,32958548,20375153,15296672,11731080,19181266,26884457,33223839,29626124,15380745,10668880,11809531,15118844,11545613,17150163,26799485,18560942,12664136,21673661,12096786,25787336,16755039,23820419,3001349,12011224,25501992,22209865,9119745,18079358,16301679,21498525,28926581,19949981,22649045,23054556,11985794,22765027,12718911,29197132,19147569,10961956,32329699,15193248,24669276,16287239,19015650,19226160,24717098,19401596,35414180,11799184,14734452,12920846,31604441,25807290,10051642,17235355,26957261,26518424,14973078,26214356,16225913,16177567,16985075,17457322,18552144,20857099,21531456,12654561,21850213,16791749,20150258,27446976,36414157,14741578,20810757,34440666,15014901,21198146,14538050,15113916,22387029,17868025,19459013,27992512,15564150,28100832,29564914,18800764,18305574,12734316,11988348,19469693,23226020,22664242,17401105,25973680,17053862,22144022,22510347,30739410,34066836,26349490,19261416,35229260,14592478,20823571,20128995,23229091,22448775,25814519,15147813,36931125,21125268,19106231,23733207,23088623,25569358,21818135,21360246,27794494,20383594,11523120,26862757,24737028,15132989,25663991,19043292,19366903,32387862,20046872,19318556,34740576,18674655,19073729,21503130,26708090,11164913,22505018,24376772,22527796,25609160,20179680,20858725,24700883,23342302,14670229,28331317,9343173,32447209,18758434,31553933,12842433,22074768,19397852,20641657,27393689,25927390,21464908,31386928,19848584,26865542,18061250,14741566,22653385,19240693,16285908,31361124,23608932,15940613,19549907,19273106,31478590,16315003,29152665,19075670,22768027,35981900,21338096,15379725,18287240,18779655,22565608,25698472,27349354,17131149,14679063,27246312,19509153,33463272,24706884,23762226,23825626,26510309,18461056,25232844,26086295,20924688,10528025,32451087,20379787,27020169,12385291,24310722,30333171,15930746,15564149,18483090,19259068,21864241,27446500,20011241,18483294,26026304,20727221,22560667,19522026,19129498,25405951,34325075,20075195,19875645,22871580,34029631,18019844,10473186,31746630,16510583,21321486,15380743,29641161,12322978,31805767,11940538,36145541,21697304,26967319,23877048,31571502,14537106,18548314,19722557,14717333,23505478,11250742,19888195,18572669,21350963,24063960,26546972,24177294,29564392,31534330,29896306,20658194,32127946,29774910,19277014,36260955,24086405,32112389,17671901,28761146,27463763,23473963,21183946,23858968,11295424,33724266,23861656,30872792,12604036,33026561,21601452,9116055,17577984,22671719,20639890,17896915,14617797,27367152,29653224,15848953,29729405,17268535,32879363,9136837,21256666,24816650,12387839,22950971,15634653,20603862,27356892,29771500,16472190,15384947,19647886,27804291,31811202,23029088,31204440,22142769,17554882,18697838,28694032,19587310,27428929,33102459,25775241,23245906,22263921,18367474,25592551,29172089,18420786,35995299,35345784,24324343,22248086,24809057,24225774,35163086,16769110,23119108,20214640,22211146,28791648,30393375,20497549,22888744,15888025,31123153,17219954,24594684,26594360,22585108,33050526,28755290,20711466,28811469,21275414,21762081,28874662,29380900,20606647,24675512,28454098,15473900,17926035,11710773,18330476,20641219,18953678,19294766,16105505,29684497,30042499,19806500,28668851,35598570,26024761,23360232,10561834,15777223,15262238,25663971,32655786,19259066,30105205,32648882,12725535,35195122,12202223,31655205,23661285,23005348,20858201,33626335,26958635,29271920,8546398,22339136,19263264,12813877,21613404,27711720,19321608,24743103,20822161,21559654,10213873,30023523,23137147,35335972,23133817,30534584,25414668,27071682,29192755,21074847,18175988,26983635,23403543,15071958,32261312,21179016,19330034,34959463,31572857,18265333,30140377,11038370,35116829,16819202,19206477,26557967,19400256,9429104,14538046,10942312,26316894,1809192,33670594,21994645,37021741,18039007,28989666,27262023,32132723[uid]

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Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene.

Xiong Z, Cheng Z, Zhang X, Patel M, Wu JC, Gambhir SS, Chen X. Xiong Z, et al. J Nucl Med. 2006 Jan;47(1):130-9. J Nucl Med. 2006. PMID: 16391197 Free PMC article.

PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene.

Miyagawa M, Anton M, Haubner R, Simoes MV, Städele C, Erhardt W, Reder S, Lehner T, Wagner B, Noll S, Noll B, Grote M, Gambhir SS, Gansbacher B, Schwaiger M, Bengel FM. Miyagawa M, et al. J Nucl Med. 2004 Nov;45(11):1917-23. J Nucl Med. 2004. PMID: 15534063 Free article.

Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression.

Chen X, Hou Y, Tohme M, Park R, Khankaldyyan V, Gonzales-Gomez I, Bading JR, Laug WE, Conti PS. Chen X, et al. J Nucl Med. 2004 Oct;45(10):1776-83. J Nucl Med. 2004. PMID: 15471848 Free article.

Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells.

Roelants V, Labar D, de Meester C, Havaux X, Tabilio A, Gambhir SS, Di Ianni M, Bol A, Bertrand L, Vanoverschelde JL. Roelants V, et al. J Nucl Med. 2008 Nov;49(11):1836-44. doi: 10.2967/jnumed.108.052175. J Nucl Med. 2008. PMID: 18984872 Free article.

Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs.

Najjar AM, Nishii R, Maxwell DS, Volgin A, Mukhopadhyay U, Bornmann WG, Tong W, Alauddin M, Gelovani JG. Najjar AM, et al. J Nucl Med. 2009 Mar;50(3):409-16. doi: 10.2967/jnumed.108.058735. Epub 2009 Feb 17. J Nucl Med. 2009. PMID: 19223410 Free article.

A tracer kinetic model for 18F-FHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET.

Green LA, Nguyen K, Berenji B, Iyer M, Bauer E, Barrio JR, Namavari M, Satyamurthy N, Gambhir SS. Green LA, et al. J Nucl Med. 2004 Sep;45(9):1560-70. J Nucl Med. 2004. PMID: 15347725 Free article.

A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs.

Likar Y, Dobrenkov K, Olszewska M, Vider E, Shenker L, Cai S, Pillarsetty N, Hricak H, Ponomarev V. Likar Y, et al. J Nucl Med. 2008 May;49(5):713-20. doi: 10.2967/jnumed.107.046425. Epub 2008 Apr 15. J Nucl Med. 2008. PMID: 18413388 Free PMC article.

PET imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [18F]FHBG.

Yaghoubi SS, Gambhir SS. Yaghoubi SS, et al. Nat Protoc. 2006;1(6):3069-75. doi: 10.1038/nprot.2006.459. Nat Protoc. 2006. PMID: 17406570

Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase.

Mizuguchi H, Hayakawa T. Mizuguchi H, et al. Cancer Gene Ther. 2002 Mar;9(3):236-42. doi: 10.1038/sj.cgt.7700440. Cancer Gene Ther. 2002. PMID: 11896439

Positron emission tomography imaging of cardiac reporter gene expression in living rats.

Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Wu JC, et al. Circulation. 2002 Jul 9;106(2):180-3. doi: 10.1161/01.cir.0000023620.59633.53. Circulation. 2002. PMID: 12105155 Free PMC article.

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