Assessment of Tau Tangles and Amyloid-β Plaques Among Super Agers Using PET Imaging

Merle C Hoenig; Niclas Willscheid; Gérard N Bischof; Thilo van Eimeren; Alexander Drzezga; Alzheimer’s Disease Neuroimaging Initiative

doi:10.1001/jamanetworkopen.2020.28337

Assessment of Tau Tangles and Amyloid-β Plaques Among Super Agers Using PET Imaging

JAMA Netw Open. 2020 Dec 1;3(12):e2028337. doi: 10.1001/jamanetworkopen.2020.28337.

Authors

Merle C Hoenig^{1

2}, Niclas Willscheid², Gérard N Bischof², Thilo van Eimeren^{2

3

4}, Alexander Drzezga^{1

2

4}; Alzheimer’s Disease Neuroimaging Initiative

Affiliations

¹ Research Center Juelich, Institute for Neuroscience and Medicine II, Molecular Organization of the Brain, Juelich, Germany.
² Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
³ Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
⁴ German Center for Neurodegenerative Diseases, Bonn, Germany.

Abstract

This cross-sectional study examines positron emission tomography (PET) imaging to investigate the burden of tau tangles and amyloid β plaques in super agers, normal agers, and patients with mild cognitive impairment vs younger amyloid-negative controls.

Publication types

Comparative Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aged, 80 and over
Aging / pathology*
Aging / psychology
Amyloid beta-Peptides / analysis*
Brain / diagnostic imaging
Brain / pathology
Cognitive Dysfunction / diagnostic imaging
Cross-Sectional Studies
Female
Humans
Male
Plaque, Amyloid / diagnostic imaging*
Positron-Emission Tomography*
Tauopathies / diagnostic imaging*
tau Proteins / analysis*

Substances

Amyloid beta-Peptides
tau Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding