Production and Supply of α-Particle-Emitting Radionuclides for Targeted α-Therapy

J Nucl Med. 2021 Nov;62(11):1495-1503. doi: 10.2967/jnumed.120.261016. Epub 2021 Jul 22.

Abstract

Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss the most promising candidates for clinical application and the state of the art of their production and supply. In this review, along with 2 forthcoming reviews on chelation and clinical application of α-emitting radionuclides, The Journal of Nuclear Medicine will provide a comprehensive assessment of the field.

Keywords: 211At; 212Pb/212Bi; 225Ac/213Bi; 227Th/223Ra; production and supply of radionuclides; targeted α-therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alpha Particles* / therapeutic use
  • Radioimmunotherapy*