A survey of reducing agents for the synthesis of tetraphenylarsonium oxotechnetiumbis(ethanedithiolate) from [99Tc] pertechnetate in aqueous solution

J Nucl Med. 1980 Mar;21(3):279-81.

Abstract

We have studied the effectiveness of various reducing agents in the production of the well-characterized complex [99TcO(SCH2CH2S)2]- from pertechnetate in aqueous solution. The reductants tested included sodium dithionite, hypophosphorous acid, formamidine sulfinic acid, dithiothreitol, hydrazine, and hydroxylamine. Of these, only sodium dithionite in the pH range 11--13 was found to give quantitative yields of the required technetium complex.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arsenicals*
  • Dithionite
  • Dithiothreitol
  • Hydrazines
  • Hydrogen-Ion Concentration
  • Hydroxylamines
  • Organotechnetium Compounds*
  • Oxidation-Reduction
  • Sulfinic Acids
  • Technetium*

Substances

  • Arsenicals
  • Hydrazines
  • Hydroxylamines
  • Organotechnetium Compounds
  • Sulfinic Acids
  • Dithionite
  • tetraphenylarsonium oxotechnetiumbis(ethanedithiolate)
  • Technetium
  • Dithiothreitol