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PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.
Kroth H, Oden F, Molette J, Schieferstein H, Gabellieri E, Mueller A, Berndt M, Sreenivasachary N, Serra AM, Capotosti F, Schmitt-Willich H, Hickman D, Pfeifer A, Dinkelborg L, Stephens A. Kroth H, et al. Among authors: oden f. J Med Chem. 2021 Sep 9;64(17):12808-12830. doi: 10.1021/acs.jmedchem.1c00861. Epub 2021 Aug 29. J Med Chem. 2021. PMID: 34455780
Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.
Gabellieri E, Capotosti F, Molette J, Sreenivasachary N, Mueller A, Berndt M, Schieferstein H, Juergens T, Varisco Y, Oden F, Schmitt-Willich H, Hickman D, Dinkelborg L, Stephens A, Pfeifer A, Kroth H. Gabellieri E, et al. Among authors: oden f. Eur J Med Chem. 2020 Oct 15;204:112615. doi: 10.1016/j.ejmech.2020.112615. Epub 2020 Jul 15. Eur J Med Chem. 2020. PMID: 32771872
Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Kroth H, Oden F, Molette J, Schieferstein H, Capotosti F, Mueller A, Berndt M, Schmitt-Willich H, Darmency V, Gabellieri E, Boudou C, Juergens T, Varisco Y, Vokali E, Hickman DT, Tamagnan G, Pfeifer A, Dinkelborg L, Muhs A, Stephens A. Kroth H, et al. Among authors: oden f. Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2178-2189. doi: 10.1007/s00259-019-04397-2. Epub 2019 Jul 1. Eur J Nucl Med Mol Imaging. 2019. PMID: 31264169 Free PMC article.