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First platinum(II)-based metal-organic linker technology (Lx®) for a plug-and-play development of antibody-drug conjugates (ADCs).
Expert Opin Drug Deliv. 2019 Aug;16(8):783-793. doi: 10.1080/17425247.2019.1645118. Epub 2019 Jul 24.
Expert Opin Drug Deliv. 2019.
PMID: 31327255
An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtII Linker Lx for Improved Manufacturability of Antibody-Drug Conjugates.
Merkul E, Muns JA, Sijbrandi NJ, Houthoff HJ, Nijmeijer B, van Rheenen G, Reedijk J, van Dongen GAMS.
Merkul E, et al. Among authors: muns ja.
Angew Chem Int Ed Engl. 2021 Feb 8;60(6):3008-3015. doi: 10.1002/anie.202011593. Epub 2021 Jan 15.
Angew Chem Int Ed Engl. 2021.
PMID: 33185916
Free PMC article.
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Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice.
Xenaki KT, Dorrestijn B, Muns JA, Adamzek K, Doulkeridou S, Houthoff H, Oliveira S, van Bergen En Henegouwen PM.
Xenaki KT, et al. Among authors: muns ja.
Theranostics. 2021 Mar 13;11(11):5525-5538. doi: 10.7150/thno.57510. eCollection 2021.
Theranostics. 2021.
PMID: 33859761
Free PMC article.
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A Novel Platinum(II)-Based Bifunctional ADC Linker Benchmarked Using 89Zr-Desferal and Auristatin F-Conjugated Trastuzumab.
Sijbrandi NJ, Merkul E, Muns JA, Waalboer DC, Adamzek K, Bolijn M, Montserrat V, Somsen GW, Haselberg R, Steverink PJ, Houthoff HJ, van Dongen GA.
Sijbrandi NJ, et al. Among authors: muns ja.
Cancer Res. 2017 Jan 15;77(2):257-267. doi: 10.1158/0008-5472.CAN-16-1900. Epub 2016 Nov 21.
Cancer Res. 2017.
PMID: 27872093
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In Vivo Characterization of Platinum(II)-Based Linker Technology for the Development of Antibody-Drug Conjugates: Taking Advantage of Dual Labeling with 195mPt and 89Zr.
Muns JA, Montserrat V, Houthoff HJ, Codée-van der Schilden K, Zwaagstra O, Sijbrandi NJ, Merkul E, van Dongen GAMS.
Muns JA, et al.
J Nucl Med. 2018 Jul;59(7):1146-1151. doi: 10.2967/jnumed.117.206672. Epub 2018 Mar 1.
J Nucl Med. 2018.
PMID: 29496986
Free article.
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Platinum(II) as bifunctional linker in antibody-drug conjugate formation: coupling of a 4-nitrobenzo-2-oxa-1,3-diazole fluorophore to trastuzumab as a model.
Waalboer DC, Muns JA, Sijbrandi NJ, Schasfoort RB, Haselberg R, Somsen GW, Houthoff HJ, van Dongen GA.
Waalboer DC, et al. Among authors: muns ja.
ChemMedChem. 2015 May;10(5):797-803. doi: 10.1002/cmdc.201402496. Epub 2015 Mar 25.
ChemMedChem. 2015.
PMID: 25809281
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