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ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis.
Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. Mann JE, et al. Among authors: merkin rd. J Immunother Cancer. 2023 Aug;11(8):e007358. doi: 10.1136/jitc-2023-007358. J Immunother Cancer. 2023. PMID: 37586769 Free PMC article.
Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases.
Schoenfeld DA, Moutafi M, Martinez S, Djureinovic D, Merkin RD, Adeniran A, Braun DA, Signoretti S, Choueiri TK, Parisi F, Hurwitz M, Rimm DL, Wei W, Jilaveanu L, Kluger HM. Schoenfeld DA, et al. Among authors: merkin rd. J Immunother Cancer. 2023 Aug;11(8):e007240. doi: 10.1136/jitc-2023-007240. J Immunother Cancer. 2023. PMID: 37586773 Free PMC article.
Location matters: LAG3 levels are lower in renal cell carcinoma metastatic sites compared to primary tumors, and expression at metastatic sites only may have prognostic importance.
Schoenfeld DA, Merkin RD, Moutafi M, Martinez S, Adeniran A, Kumar D, Jilaveanu L, Hurwitz M, Rimm DL, Kluger HM. Schoenfeld DA, et al. Among authors: merkin rd. Front Oncol. 2022 Oct 13;12:990367. doi: 10.3389/fonc.2022.990367. eCollection 2022. Front Oncol. 2022. PMID: 36313654 Free PMC article.