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An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein.
Seijsing J, Lindborg M, Höidén-Guthenberg I, Bönisch H, Guneriusson E, Frejd FY, Abrahmsén L, Ekblad C, Löfblom J, Uhlén M, Gräslund T. Seijsing J, et al. Among authors: lindborg m. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17110-5. doi: 10.1073/pnas.1417717111. Epub 2014 Nov 18. Proc Natl Acad Sci U S A. 2014. PMID: 25406323 Free PMC article.